{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T16:39:08Z","timestamp":1790872748881,"version":"4.1.0"},"reference-count":25,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,7,31]],"date-time":"2024-07-31T00:00:00Z","timestamp":1722384000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Gynecology &amp; Obste"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>In the present study, we aimed to compare serum CK\u2010MM levels in patients with and without adenomyosis and to investigate whether CK\u2010MM level can be a non\u2010invasive marker for myometrial damage due to adenomyosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Our study was a prospective case\u2010control study in a tertiary center and consisted of 40 patients with a clinical\/ultrasonographic diagnosis of adenomyosis and 40 patients without a clinical\/ultrasonographic diagnosis of adenomyosis as the control group based on recently published morphological uterus sonographic assessment (MUSA) criteria. Individuals of similar age who signed a voluntary consent form were included in our study. Demographic, clinical, and laboratory findings of the patients in both groups were recorded. Blood serum samples were used for the determination of serum CK\u2010MM levels of the participants in our study. The samples were analyzed by using the human CK\u2010MM enzyme\u2010linked immunosorbent assay (ELISA) kit.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In our study, the mean serum CK\u2010MM level was 16.2\u2009\u00b1\u200921.7 (ng\/dL) in patients with adenomyosis and 2.6\u2009\u00b1\u20092.2 (ng\/dL) in patients without adenomyosis. Serum CK\u2010MM level was statistically significantly higher in the patient group with adenomyosis than in the control group (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). The CK\u2010MM threshold value of 3.43\u2009ng\/mL, with a sensitivity of 82.5% and specificity of 85%, has been found to be a valuable distinguishing level in patients with and without adenomyosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In this study, we demonstrated that serum CK\u2010MM can be used as a non\u2010invasive diagnostic method in patients with adenomyosis. As the number of studies around this subject in the literature is insufficient, larger studies are needed to use CK\u2010MM as a diagnostic marker in adenomyosis.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ijgo.15824","type":"journal-article","created":{"date-parts":[[2024,7,31]],"date-time":"2024-07-31T07:40:11Z","timestamp":1722411611000},"page":"314-319","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Value of serum muscular creatinine phosphokinase levels in patients with adenomyosis as a non\u2010invasive diagnostic marker"],"prefix":"10.1002","volume":"168","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0645-4786","authenticated-orcid":false,"given":"Hilal M\u00fcr\u00fcvvet","family":"Bulut Aydemir","sequence":"first","affiliation":[{"name":"Gynecology and Obstetrics Department University of Health Sciences Ankara City Hospital  Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8964-3552","authenticated-orcid":false,"given":"Serkan","family":"Kahyao\u011flu","sequence":"additional","affiliation":[{"name":"Gynecology and Obstetrics Department University of Health Sciences Ankara City Hospital  Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3078-8420","authenticated-orcid":false,"given":"\u0130nci","family":"Halilzade","sequence":"additional","affiliation":[{"name":"Gynecology and Obstetrics Department University of Health Sciences Ankara City Hospital  Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8167-3837","authenticated-orcid":false,"given":"\u00d6zlem","family":"Moralo\u011flu\u2010Tekin","sequence":"additional","affiliation":[{"name":"Gynecology and Obstetrics Department University of Health Sciences Ankara City Hospital  Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,7,31]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0040-1716687"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmig.2015.09.018"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2019.02.008"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpobgyn.2016.09.006"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmig.2013.11.011"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016349.2010.512061"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41589-023-01273-x"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijns5030027"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00726-020-02896-3"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1159\/000502822"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.14806"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpobgyn.2018.01.013"},{"key":"e_1_2_8_14_1","first-page":"1078","article-title":"CA 125 and other tumor markers in uterine leiomyomas and their association with lesion characteristics","volume":"7","author":"Babacan A","year":"2014","journal-title":"Int J Clin Exp Med"},{"key":"e_1_2_8_15_1","first-page":"33","article-title":"Adenomyosis: diagnosis and management","volume":"105","author":"Schrager S","year":"2022","journal-title":"Am Fam Physician"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00404-011-2180-7"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2010.03.015"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/des332"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2020.01.016"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dex088"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.14834"},{"key":"e_1_2_8_22_1","first-page":"176","article-title":"Understanding clinical features of adenomyosis: a case control study","volume":"14","author":"Shrestha A","year":"2012","journal-title":"Nepal Med Coll J"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmig.2020.11.001"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(93)90272-K"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijgo.2007.03.052"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s43032-020-00262-y"}],"container-title":["International Journal of Gynecology &amp; Obstetrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijgo.15824","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,17]],"date-time":"2025-01-17T12:21:36Z","timestamp":1737116496000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1002\/ijgo.15824"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7,31]]},"references-count":25,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,1]]}},"alternative-id":["10.1002\/ijgo.15824"],"URL":"https:\/\/doi.org\/10.1002\/ijgo.15824","archive":["Portico"],"relation":{},"ISSN":["0020-7292","1879-3479"],"issn-type":[{"value":"0020-7292","type":"print"},{"value":"1879-3479","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,7,31]]},"assertion":[{"value":"2024-05-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-07-13","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-07-31","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}