{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,12]],"date-time":"2025-07-12T22:52:20Z","timestamp":1752360740072,"version":"3.33.0"},"reference-count":25,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,7,28]],"date-time":"2024-07-28T00:00:00Z","timestamp":1722124800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Gynecology &amp; Obste"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To investigate the contribution of longitudinal mean arterial pressure (MAP) measurement during the first, second, and third trimesters of twin pregnancies to the prediction of pre\u2010eclampsia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective cohort study was conducted on women with twin pregnancies. Historical data between 2019 and 2021 were analyzed, including maternal characteristics and mean artery pressure measurements were obtained at 11\u201313, 22\u201324, and 28\u201333\u2009weeks of gestation. The outcome measures included pre\u2010eclampsia with delivery &lt;34 and \u226534\u2009weeks of gestation. Models were developed using logistic regression, and predictive performance was evaluated using the area under the curve, detection rate at a given false\u2010positive rate of 10%, and calibration plots. Internal validation was conducted via bootstrapping.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 943 twin pregnancies, including 36 (3.82%) women who experienced early\u2010onset pre\u2010eclampsia and 93 (9.86%) who developed late\u2010onset pre\u2010eclampsia, were included in this study. To forecast pre\u2010eclampsia during the third trimester, the most accurate prediction for early\u2010onset pre\u2010eclampsia resulted from a combination of maternal factors and MAP measured during this trimester. The optimal predictive model for late\u2010onset pre\u2010eclampsia includes maternal factors and MAP data collected during the second and third trimesters. The areas under the curve were 0.937 (95% confidence interval [CI] 0.894\u20130.981) and 0.887 (95% CI 0.852\u20130.921), respectively. The corresponding detection rates were 83.33% (95% CI 66.53%\u201393.04%) for early\u2010onset pre\u2010eclampsia and 68.82% (95% CI 58.26%\u201377.80%) for late\u2010onset pre\u2010eclampsia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Repeated measurements of MAP during pregnancy significantly improved the accuracy of late\u2010onset pre\u2010eclampsia prediction in twin pregnancies. The integration of longitudinal data into pre\u2010eclampsia screening may be an effective and valuable strategy.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ijgo.15825","type":"journal-article","created":{"date-parts":[[2024,7,29]],"date-time":"2024-07-29T05:29:20Z","timestamp":1722230960000},"page":"196-204","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["The potential of repeated mean arterial pressure measurements for predicting early\u2010 and late\u2010onset pre\u2010eclampsia in twin pregnancies: Prediction model study"],"prefix":"10.1002","volume":"168","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-0326-3954","authenticated-orcid":false,"given":"Yunjiang","family":"He","sequence":"first","affiliation":[{"name":"School of Public Health Shanghai Jiao Tong University School of Medicine  Shanghai China"},{"name":"Department of Biostatistics, Clinical Research Institute Shanghai Jiao Tong University School of 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