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However, because of its rarity, there is still no standardized treatment regimen. A 34\u2010year\u2010old Gravida 1 Para 0 (0010) was diagnosed with GTN with metastasis to the lumbosacral spine, resulting in conus medullaris syndrome with lumbar radiculopathy. She presented with a 14\u2010month history of amenorrhea, left lower extremity pain, and urinary and bowel retention. On examination, there was a 10.0\u2009\u00d7\u20097.0\u2009cm lumbosacral mass and atrophy of the left lower extremity. Transvaginal ultrasound showed a cul de sac mass, and diluted \u03b2\u2010human chorionic gonadotropin (\u03b2\u2010hCG) titer was markedly elevated at more than 1000\u2009000 mIU\/mL. Magnetic resonance imaging (MRI) of the lumbosacral spine showed an ill\u2010defined sacral mass measuring 13.3\u2009\u00d7\u200911.5\u2009\u00d7\u20096.3\u2009cm with spinal canal, bone, muscle, and nerve root involvement. She was treated with 10\u2009cycles of EMACO and palliative radiotherapy with 10 sessions of 30\u2009Gy of external beam radiation therapy directed toward the lumbosacral mass. Repeat MRI showed a decrease in size of the mass to 6.6\u2009\u00d7\u20098.2\u2009\u00d7\u20094.1\u2009cm with concurrent decrease in \u03b2\u2010hCG to 1.30 mIU\/ml, and resolution of leg pain and urinary and bowel symptoms. She was declared to be in remission 3\u2009months after the last cycle of EMACO.<\/jats:p>","DOI":"10.1002\/ijgo.15834","type":"journal-article","created":{"date-parts":[[2024,8,6]],"date-time":"2024-08-06T09:29:32Z","timestamp":1722936572000},"page":"94-100","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Diagnosis and management of a case of gestational trophoblastic neoplasia with lumbosacral metastases"],"prefix":"10.1002","volume":"168","author":[{"given":"Jemuel M.","family":"Dela Cruz","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology University of the Philippines Manila\u2014Philippine General Hospital  Manila Philippines"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anathea V.","family":"De La Pe\u00f1a","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology University of the Philippines Manila\u2014Philippine General Hospital  Manila Philippines"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gellie Anne C.","family":"Maglasang\u2010Lucas","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology University of the Philippines Manila\u2014Philippine General Hospital  Manila Philippines"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-4719-5185","authenticated-orcid":false,"given":"Ana Patricia C.","family":"Vargas","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology University of the Philippines Manila\u2014Philippine General Hospital  Manila Philippines"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Filomena S.","family":"San Juan","sequence":"additional","affiliation":[{"name":"Division of Trophoblastic Diseases, Department of Obstetrics and Gynecology University of the Philippines Manila\u2014Philippine General Hospital  Manila Philippines"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,8,6]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.4038\/sljm.v30i1.210"},{"volume-title":"Comprehensive Gynecology","year":"2021","author":"Gershenson DM","key":"e_1_2_8_3_1"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.4172\/2165-7939.1000336"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.3340\/jkns.2010.47.2.143"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/brs.0b013e3181a98746"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.3340\/jkns.2012.51.3.141"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.47739\/2373-938X\/1019"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00404-007-0469-3"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2003.09.029"},{"key":"e_1_2_8_11_1","first-page":"207","article-title":"Lesions of testes observed in certain patients with widespread choriocarcinoma and related tumors. 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