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PIH were diagnosed according to international guidelines, and defined as gestational hypertension (GH, <jats:italic>n<\/jats:italic>\u2009=\u200961) or pre\u2010eclampsia (<jats:italic>n<\/jats:italic>\u2009=\u200974). VEGFR\u20103 was measured in plasma using ELISA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Plasma VEGFR\u20103 was increased in HP (1207\u2009pg\/mL) compared with NP (133\u2009pg\/mL) women; however, PIH (729\u2009pg\/mL) patients exhibited lower levels than HP women (both <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). In addition, plasma VEGFR\u20103 was decreased in pre\u2010eclampsia compared with GH (537 versus 980\u2009pg\/mL; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). When pre\u2010eclampsia was classified according to different clinical presentations, plasma VEGFR\u20103 was further decreased in the cases identified as pre\u2010eclampsia with severe features, preterm pre\u2010eclampsia, and pre\u2010eclampsia accompanied by small for gestational age (all <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our data indicate reduced circulating VEGFR\u20103 levels in patients with PIH, specifically in those diagnosed with pre\u2010eclampsia. Moreover, decreased VEGFR\u20103 was associated with adverse clinical outcomes in pre\u2010eclampsia. These findings expand previous evidence of reduced VEGFR\u20103 expression in pre\u2010eclampsia. Future studies should investigate whether it can be used as a predictive biomarker and\/or therapeutic target for pre\u2010eclampsia.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ijgo.15838","type":"journal-article","created":{"date-parts":[[2024,8,7]],"date-time":"2024-08-07T08:50:33Z","timestamp":1723020633000},"page":"210-219","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Circulating vascular endothelial growth factor receptor\u20103, a pro\u2010lymphangiogenic and pro\u2010angiogenic mediator, is decreased in pre\u2010eclampsia"],"prefix":"10.1002","volume":"168","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2669-5301","authenticated-orcid":false,"given":"Ana C.","family":"Palei","sequence":"first","affiliation":[{"name":"Department of Surgery, School of Medicine University of Mississippi Medical Center (UMMC)  Jackson Mississippi USA"},{"name":"Cardiovascular\u2010Renal Research Center, School of Medicine University of Mississippi Medical Center (UMMC)  Jackson Mississippi USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julyane N. 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