{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T14:26:26Z","timestamp":1793888786944,"version":"4.8.0"},"reference-count":14,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,9,8]],"date-time":"2024-09-08T00:00:00Z","timestamp":1725753600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2024,9,8]],"date-time":"2024-09-08T00:00:00Z","timestamp":1725753600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Gynecology &amp; Obste"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To explore the effectiveness of HPV 16\/18 E7 oncoprotein in detecting high\u2010grade cervical intraepithelial neoplasia (CIN) and predicting disease outcomes in HPV 16\/18\u2010positive patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The present study was a cross\u2010sectional study with a 2\u2010year follow up. We collected 915 cervical exfoliated cell samples from patients who tested positive for HPV 16\/18 in gynecologic clinics of three tertiary hospitals in Beijing from March 2021 to October 2022 for HPV 16\/18 E7 oncoprotein testing. Subsequently, 2\u2010year follow up of 408 patients with baseline histologic CIN1 or below were used to investigate the predictive role of HPV 16\/18 E7 oncoprotein in determining HPV persistent infection and disease progression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The positivity rate of the HPV 16\/18 E7 oncoprotein assay was 42.06% (249\/592) in the inflammation\/CIN 1 group and 85.45% (277\/324) in the CIN2+ group. For CIN2+ detection, using the HPV 16\/18 E7 oncoprotein assay combined with HPV 16\/18 testing, the sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) were 85.45%, 57.94%, 52.57%, and 87.95%, respectively. During the 2\u2010year follow up, the sensitivity, specificity, PPV, and NPV for predicting persistent HPV infection were 48.44%, 58.21%, 34.64%, and 71.18% in the baseline inflammation and CIN1 group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>As a triage method for high\u2010grade CIN screening in HPV 16\/18\u2010positive patients, HPV 16\/18 E7 oncoprotein demonstrated a relatively high NPV, making it suitable for clinical use in triaging HPV 16\/18\u2010positive cases and potentially reducing the colposcopic referral rate. HPV 16\/18 E7 oncoprotein exhibited a preferably predictive value in determining HPV infection outcomes and disease progression.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ijgo.15897","type":"journal-article","created":{"date-parts":[[2024,9,8]],"date-time":"2024-09-08T03:09:03Z","timestamp":1725764943000},"page":"545-550","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["<scp>HPV<\/scp>\n                    16\/18\n                    <scp>E7<\/scp>\n                    oncoprotein detection as a promising triage strategy for\n                    <scp>HPV<\/scp>\n                    16\/18\u2010positive patients: A prospective multicenter study with a 2\u2010year follow up"],"prefix":"10.1002","volume":"168","author":[{"given":"Yang","family":"Cao","sequence":"first","affiliation":[{"name":"National Clinical Research Center for Obstetric &amp; Gynecologic Diseases, Department of Obstetrics and Gynecology, Peking Union Medical College Hospital Chinese Academy of Medical Sciences &amp; Peking Union Medical College  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoping","family":"Xiao","sequence":"additional","affiliation":[{"name":"National Clinical Research Center for Obstetric &amp; Gynecologic Diseases, Department of Obstetrics and Gynecology, Peking Union Medical College Hospital Chinese Academy of Medical Sciences &amp; Peking Union Medical College  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dandan","family":"Liang","sequence":"additional","affiliation":[{"name":"National Clinical Research Center for Obstetric &amp; Gynecologic Diseases, Department of Obstetrics and Gynecology, Peking Union Medical College Hospital Chinese Academy of Medical Sciences &amp; Peking Union Medical College  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ye","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Peking University First Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chongdong","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Beijing Chao\u2010Yang Hospital Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Beijing Chao\u2010Yang Hospital Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Wang","sequence":"additional","affiliation":[{"name":"National Clinical Research Center for Obstetric &amp; Gynecologic Diseases, Department of Obstetrics and Gynecology, Peking Union Medical College Hospital Chinese Academy of Medical Sciences &amp; Peking Union Medical College  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junjun","family":"Yang","sequence":"additional","affiliation":[{"name":"National Clinical Research Center for Obstetric &amp; Gynecologic Diseases, Department of Obstetrics and Gynecology, Peking Union Medical College Hospital Chinese Academy of Medical Sciences &amp; Peking Union Medical College  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinhui","family":"Wang","sequence":"additional","affiliation":[{"name":"National Clinical Research Center for Obstetric &amp; Gynecologic Diseases, Department of Obstetrics and Gynecology, Peking Union Medical College Hospital Chinese Academy of Medical Sciences &amp; Peking Union Medical College  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Li","sequence":"additional","affiliation":[{"name":"National Clinical Research Center for Obstetric &amp; Gynecologic Diseases, Department of Obstetrics and Gynecology, Peking Union Medical College Hospital Chinese Academy of Medical Sciences &amp; Peking Union Medical College  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caijuan","family":"Li","sequence":"additional","affiliation":[{"name":"National Clinical Research Center for Obstetric &amp; Gynecologic Diseases, Department of Obstetrics and Gynecology, Peking Union Medical College Hospital Chinese Academy of Medical Sciences &amp; Peking Union Medical College  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruoli","family":"Guan","sequence":"additional","affiliation":[{"name":"National Clinical Research Center for Obstetric &amp; Gynecologic Diseases, Department of Obstetrics and Gynecology, Peking Union Medical College Hospital Chinese Academy of Medical Sciences &amp; Peking Union Medical College  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dai","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Peking University First Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Bi","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Peking University First Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Peking University First Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Qu","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Beijing Chao\u2010Yang Hospital Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Xu","sequence":"additional","affiliation":[{"name":"Institute of Basic Medical Sciences, Peking Union Medical College Chinese Academy of Medical Sciences  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Peking Union Medical College Hospital Chinese Academy of Medical Sciences &amp; 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