{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T14:26:26Z","timestamp":1793888786987,"version":"4.8.0"},"reference-count":24,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,9,15]],"date-time":"2024-09-15T00:00:00Z","timestamp":1726358400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2024,9,15]],"date-time":"2024-09-15T00:00:00Z","timestamp":1726358400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2023M743203"],"award-info":[{"award-number":["2023M743203"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Gynecology &amp; Obste"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To explore the assisted reproductive outcomes of patients with atypical endometrial hyperplasia (AEH) and early\u2010stage endometrial cancer (EEC) who achieved complete remission after conservative treatment and to provide reference for clinical selection of appropriate conservative treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>This retrospective cohort study included seven patients with EEC and 62 patients with AEH who underwent in\u00a0vitro fertilization or intracytoplasmic sperm injection at the Reproductive Center of the Third Affiliated Hospital of Zhengzhou University between August 2015 and October 2023. The authors divided the participants into two groups based on the type of fertility\u2010sparing treatment received: the oral medication group and the levonorgestrel\u2010releasing intrauterine system (LNG\u2010IUS) group. The primary outcome was the cumulative clinical pregnancy rate. Secondary outcomes included clinical pregnancy rate per transfer cycle, embryo utilization rate, and high\u2010quality embryo rate.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The LNG\u2010IUS group had a significantly higher rate of usable embryos compared with the oral medication group (80.8% vs 91.1%,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.005) and also had a thinner endometrial thickness on the day of embryo transfer. The cumulative clinical pregnancy rate was higher in the LNG\u2010IUS group compared with the medication group (46.7% vs 78.9%,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.037), and the difference was statistically significant.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>For patients with AEH and EEC with fertility needs, the conservative treatment method of LNG\u2010IUS can achieve better assisted reproductive outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ijgo.15898","type":"journal-article","created":{"date-parts":[[2024,9,15]],"date-time":"2024-09-15T10:03:18Z","timestamp":1726394598000},"page":"598-604","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Analysis of assisted reproductive outcomes in patients with atypical endometrial hyperplasia and early\u2010stage endometrial cancer after fertility\u2010sparing treatment"],"prefix":"10.1002","volume":"168","author":[{"given":"Jiaheng","family":"Li","sequence":"first","affiliation":[{"name":"Reproduction Center The Third Affiliated Hospital of Zheng Zhou University  Henan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengnuo","family":"Li","sequence":"additional","affiliation":[{"name":"Reproduction Center The Third Affiliated Hospital of Zheng Zhou University  Henan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yijiang","family":"Li","sequence":"additional","affiliation":[{"name":"Reproduction Center The Third Affiliated Hospital of Zheng Zhou University  Henan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianling","family":"Zhao","sequence":"additional","affiliation":[{"name":"Reproduction Center The Third Affiliated Hospital of Zheng Zhou University  Henan 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