{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T00:28:08Z","timestamp":1788481688709,"version":"build-2803163510"},"reference-count":31,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,10,14]],"date-time":"2024-10-14T00:00:00Z","timestamp":1728864000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2024,10,14]],"date-time":"2024-10-14T00:00:00Z","timestamp":1728864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Gynecology &amp; Obste"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To assess adverse obstetric and neonatal outcomes associated with the use of dinoprostone for induction of labor, with particular attention on categories for which caution is recommended by the Italian Medicines Agency and the European Medicine Agency.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A retrospective multicenter observational study was conducted on a population of 1687 patients undergoing induction of labor with vaginal dinoprostone (gel or insert) between August 2019 and June 2022. Patients were subdivided based on maternal age, gestational age, and obstetric disorders. Data regarding the mode of delivery, the incidence of tachysystole, and the obstetric and perinatal outcomes were collected.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The main adverse event associated with the use of dinoprostone was tachysystole. However, tachysystole was not associated with an increased risk of cesarean section (CS), neonatal intensive care (NICU) admission, low 1\u2010min Apgar, or umbilical cord acidosis. Maternal age greater than 35\u2009years, gestational age greater than 40\u2009weeks, and obstetric disorders were not associated with an increased rate of tachysystole, NICU admission, low 1\u2010 and 5\u2010min Apgar scores, and cord acidosis. The only associated adverse outcomes in those categories were postpartum hemorrhage with age greater than 35\u2009years and tachysystole with gestational diabetes mellitus and hypertensive disorders. Not a single case of severe outcome (disseminated intravascular coagulation, uterine rupture, maternal and fetal death) was reported in the cohort.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Providing there is adequate maternal and fetal surveillance, in an inpatient setting, dinoprostone could be safely administered for the induction of labor and considered appropriate in high\u2010risk pregnancies. Tachysystole can be self\u2010identified by the patient and effectively managed.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ijgo.15952","type":"journal-article","created":{"date-parts":[[2024,10,14]],"date-time":"2024-10-14T10:13:38Z","timestamp":1728900818000},"page":"1039-1046","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Safety of the use of dinoprostone gel and vaginal insert for induction of labor: A multicenter retrospective cohort study"],"prefix":"10.1002","volume":"168","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8248-929X","authenticated-orcid":false,"given":"Mariarosaria","family":"Di Tommaso","sequence":"first","affiliation":[{"name":"Division of Obstetrics and Gynecology, Department of Health Sciences University of Florence  Florence Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosamaria","family":"Pellegrini","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical Sciences for Mother, Child and Adult University of Modena and Reggio Emilia, Azienda Ospedaliero Universitaria Policlinico  Modena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oumaima","family":"Ammar","sequence":"additional","affiliation":[{"name":"Division of Obstetrics and Gynecology, Department of Health Sciences University of Florence  Florence Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Serena","family":"Lecis","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical Sciences for Mother, Child and Adult University of Modena and Reggio Emilia, Azienda Ospedaliero Universitaria Policlinico  Modena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mor","family":"Huri","sequence":"additional","affiliation":[{"name":"Division of Obstetrics and Gynecology, Department of Health Sciences University of Florence  Florence Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabio","family":"Facchinetti","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical Sciences for Mother, Child and Adult University of Modena and Reggio Emilia, Azienda Ospedaliero Universitaria Policlinico  Modena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,10,14]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/OGX.0000000000000752"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0b013e3181b48ef5"},{"key":"e_1_2_8_4_1","first-page":"1","article-title":"Births in the United States, 2020","volume":"418","author":"Martin JA","year":"2021","journal-title":"NCHS Data Brief"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2023.02.009"},{"key":"e_1_2_8_6_1","volume-title":"StatPearls [Internet]","author":"Gill P","year":"2023"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0301-2115(02)00069-6"},{"key":"e_1_2_8_8_1","first-page":"33","article-title":"Safety and efficacy of misoprostol and dinoprostone as cervical ripening agents","volume":"49","author":"Shakya R","year":"2010","journal-title":"JNMA J Nepal Med Assoc"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/jog.14472"},{"key":"e_1_2_8_10_1","unstructured":"Agenzia Italiana del Farmaco.Nota Informativa Importante su Prepidil E Propess (Dinoprostone).2021.https:\/\/www.aifa.gov.it\/documents\/20142\/1313724\/2021.07.15_NII_Prepidil\u2010Propess_IT.pdf"},{"key":"e_1_2_8_11_1","unstructured":"European Perinatal Health Report.Core Indicators of the Health and Care of Pregnant Women and Babies in Europe From 2015 to 2019.www.europeristat.com\/index.php\/reports\/ephr\u20102019"},{"key":"e_1_2_8_12_1","unstructured":"Realizzato dalla Fondazione Confalonieri Ragonese Su Mandato SIGO AA.Induzione al Travaglio di Parto.2022.https:\/\/www.sigo.it\/wpcontent\/uploads\/2022\/02\/LG15_Induzione_Travaglio_Parto.pdf"},{"key":"e_1_2_8_13_1","unstructured":"National Institute for Health and Care Excellence (NICE).Inducing Labour.2021.www.nice.org.uk\/guidance\/ng207"},{"key":"e_1_2_8_14_1","unstructured":"World Health Organization.WHO Recommendations. 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