{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T13:44:48Z","timestamp":1780321488333,"version":"3.54.1"},"reference-count":19,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,10,19]],"date-time":"2024-10-19T00:00:00Z","timestamp":1729296000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2024,10,19]],"date-time":"2024-10-19T00:00:00Z","timestamp":1729296000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["PJT\u2010162300"],"award-info":[{"award-number":["PJT\u2010162300"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000156","name":"Fonds de Recherche du Qu\u00e9bec - Sant\u00e9","doi-asserted-by":"publisher","award":["296785"],"award-info":[{"award-number":["296785"]}],"id":[{"id":"10.13039\/501100000156","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Gynecology &amp; Obste"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To evaluate the association between gestational trophoblastic disease and the subsequent risk of developing non\u2010trophoblastic cancer.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a retrospective cohort study of 3084 women with gestational trophoblastic disease and 1\u2009415\u2009812 women with obstetric deliveries in Quebec, Canada, between 1989 and 2021. The main exposure was gestational trophoblastic disease, including hydatidiform moles, invasive moles, and gestational choriocarcinoma. The outcome was development of non\u2010trophoblastic cancer during 33\u2009years of follow\u2010up. We measured the association of gestational trophoblastic disease with non\u2010trophoblastic cancer using adjusted hazard ratios (HR) and 95% confidence intervals (CI), and tested whether associations were stronger for certain types of cancer or cancers with later onset.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The incidence of non\u2010trophoblastic cancer was greater for women with invasive moles (47.1\/10\u2009000 person\u2010years) and gestational choriocarcinoma (59.3\/10\u2009000 person\u2010years) than hydatidiform moles (18.4\/10\u2009000 person\u2010years) and no gestational trophoblastic disease (22.4\/10\u2009000 person\u2010years). Gestational choriocarcinoma (HR 2.33, 95% CI: 1.35\u20134.01;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.002) and invasive moles (HR 1.97, 95% CI: 1.06\u20133.65;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.033) were associated with an elevated risk of non\u2010trophoblastic cancer compared with no gestational trophoblastic disease, while hydatidiform moles were not. Gestational choriocarcinoma and invasive moles were mainly associated with gynecologic cancer. However, risk of cancer was limited to the short\u2010term period after pregnancy and became similar to no gestational trophoblastic disease by the end of follow\u2010up.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>While invasive moles and gestational choriocarcinoma appear to be associated with the subsequent development of non\u2010trophoblastic cancer, the absolute risk is small and limited to the short\u2010term.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ijgo.15976","type":"journal-article","created":{"date-parts":[[2024,10,19]],"date-time":"2024-10-19T07:09:48Z","timestamp":1729321788000},"page":"1305-1311","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Association of gestational trophoblastic disease with subsequent development of non\u2010trophoblastic cancer"],"prefix":"10.1002","volume":"168","author":[{"given":"Blaise","family":"Munyakarama","sequence":"first","affiliation":[{"name":"Department of Social and Preventive Medicine, School of Public Health University of Montreal  Montreal Quebec Canada"},{"name":"Health Innovation and Evaluation Hub University of Montreal Hospital Research Centre  Montreal Quebec Canada"},{"name":"Bureau d'information et d'\u00e9tudes en sant\u00e9 des populations Institut national de sant\u00e9 publique du Qu\u00e9bec  Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anita","family":"Koushik","sequence":"additional","affiliation":[{"name":"Department of Social and Preventive Medicine, School of Public Health University of Montreal  Montreal Quebec Canada"},{"name":"Health Innovation and Evaluation Hub University of Montreal Hospital Research Centre  Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Val\u00e9rie","family":"Leduc","sequence":"additional","affiliation":[{"name":"Department of Pathology McGill University  Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica","family":"Healy\u2010Profit\u00f3s","sequence":"additional","affiliation":[{"name":"Health Innovation and Evaluation Hub University of Montreal Hospital Research Centre  Montreal Quebec Canada"},{"name":"Bureau d'information et d'\u00e9tudes en sant\u00e9 des populations Institut national de sant\u00e9 publique du Qu\u00e9bec  Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2412-0459","authenticated-orcid":false,"given":"Nathalie","family":"Auger","sequence":"additional","affiliation":[{"name":"Department of Social and Preventive Medicine, School of Public Health University of Montreal  Montreal Quebec Canada"},{"name":"Health Innovation and Evaluation Hub University of Montreal Hospital Research Centre  Montreal Quebec Canada"},{"name":"Bureau d'information et d'\u00e9tudes en sant\u00e9 des populations Institut national de sant\u00e9 publique du Qu\u00e9bec  Montreal Quebec Canada"},{"name":"Department of Epidemiology, Biostatistics and Occupational Health McGill University  Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,10,19]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijgo.13877"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2021.10.003"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjmed-2022-000321"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2022.03.039"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0042-1742681"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2014.05.004"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2014.57.5332"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2008.04.011"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1023\/a:1008915217389"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(99)70504-1"},{"key":"e_1_2_10_12_1","unstructured":"Ministry of Health and Social Services.Med\u2010Echo System Normative Framework\u2010Maintenance and Use of Data for the Study of Hospital Clientele.2022.https:\/\/publications.msss.gouv.qc.ca\/msss\/fichiers\/2000\/00\u2010601_modif2022.pdf"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jogc.2020.03.001"},{"key":"e_1_2_10_14_1","unstructured":"Minist\u00e8re de la Sant\u00e9 et des Services sociaux.Registre qu\u00e9b\u00e9cois du cancer. Donn\u00e9es sur l'incidence du cancer au Qu\u00e9bec en 2013 et principaux changements. Programme qu\u00e9b\u00e9cois de canc\u00e9rologie.2021.https:\/\/publications.msss.gouv.qc.ca\/msss\/fichiers\/2021\/21\u2010902\u201024W.pdf"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF03403824"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-22-0132"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/CEJ.0000000000000763"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.29475"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-4644(2000)77:34 <1::AID-JCB2>3.0.CO;2-G"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.6061\/clinics\/2020\/e1724"}],"container-title":["International Journal of Gynecology &amp; Obstetrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijgo.15976","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ijgo.15976","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijgo.15976","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T07:56:43Z","timestamp":1771315003000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1002\/ijgo.15976"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,19]]},"references-count":19,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,3]]}},"alternative-id":["10.1002\/ijgo.15976"],"URL":"https:\/\/doi.org\/10.1002\/ijgo.15976","archive":["Portico"],"relation":{},"ISSN":["0020-7292","1879-3479"],"issn-type":[{"value":"0020-7292","type":"print"},{"value":"1879-3479","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10,19]]},"assertion":[{"value":"2024-02-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-10-07","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-10-19","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}