{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T17:13:25Z","timestamp":1773681205113,"version":"3.50.1"},"reference-count":21,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,11,6]],"date-time":"2024-11-06T00:00:00Z","timestamp":1730851200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Gynecology &amp; Obste"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>The study presents the risk of the maternal\u2010fetal morbidity and mortality among one of the largest cohort of sickle cell disease (SCD) pregnancies in India and reports the epidemiology of the maternal morbidity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a retrospective cohort study conducted at Kasturba Maternity Hospital, SEWA Rural, in the tribal area of Gujarat, India. All pregnant women admitted to the Hospital between 2016 and 2021 were screened for SCD, and their maternal\u2010fetal morbidities were recorded throughout the pregnancy. We quantified risk of maternal\u2010fetal morbidity and mortality among SCD, trait and normal pregnancies after adjusting for potential confounders using Poisson and logistic regression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 24\u2009256 delivered during the study period, with 354 (1.5%) and 4216 (17.4%) suffering from SCD and trait, respectively. After adjusting for potential confounders, the women with SCD pregnancy had higher risk of maternal death (adjusted\u2010odds\u2010ratio [AOR] 13.7, 95% CI: 4.5\u201342.7), anemia (AOR 6.8, 95% CI: 4.5\u201310.2), severe anemia (AOR 4.3, 95% CI: 3.3\u20135.6), preterm delivery (AOR 4.5, 95% CI: 3.6\u20135.7), cesarean section (AOR 5.5, 95% CI: 4.7\u20137.0), stillbirth (AOR 3.4, 95% CI: 2.3\u20135.3), and low birth weight (AOR 3.1, 95% CI: 2.4\u201339) compared to normal pregnancies. Maternal morbidities occurred throughout the pregnancy; however, the risk was highest during the last month of pregnancy. Pregnant women who had severe manifestation of SCD before the pregnancy were at higher risk of developing maternal morbidities.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>We concluded that SCD might be an independent risk\u2010factor for developing maternal\u2010fetal morbidities. The SCD pregnancies with prior severe manifestations must be carefully managed during the last month of pregnancy when the risk is highest.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ijgo.15999","type":"journal-article","created":{"date-parts":[[2024,11,6]],"date-time":"2024-11-06T11:19:34Z","timestamp":1730891974000},"page":"292-298","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Adverse maternal and fetal outcomes among tribal pregnant women suffering from sickle cell disease: A retrospective cohort study in a community\u2010based hospital situated in a tribal block of Gujarat, India"],"prefix":"10.1002","volume":"169","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3815-7292","authenticated-orcid":false,"given":"Kapilkumar","family":"Dave","sequence":"first","affiliation":[{"name":"CHP Department Society for Education, Welfare &amp; Action (SEWA)\u2010 Rural  Jhagadia Bharuch Gujarat India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shrey","family":"Desai","sequence":"additional","affiliation":[{"name":"CHP Department Society for Education, Welfare &amp; 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