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After infection, various alterations occur in the host, facilitating the virus's evasion of immune system clearance and promoting its proliferation. Oral probiotic consumption can influence the whole body's immunity, inflammatory reflection, neural, endocrine humoral, metabolic pathways and other organs by adjusting the components of gut microbiota (GM). Some evidence shows there is a tight connection between GM and vaginal microbiota (VM), which is referred to as the gut\u2010vaginal axis. This review investigates the potential role of probiotics in clearing HPV via the gut\u2010vagina axis, emphasizing the effectiveness of <jats:italic>Lactobacillus<\/jats:italic> in preventing vaginal diseases and suggesting its potential for HPV clearance. Understanding the role of probiotics in the gut\u2010vagina axis could pave the way for new strategies to reduce and eliminate HPV and related diseases.<\/jats:p>","DOI":"10.1002\/ijgo.16005","type":"journal-article","created":{"date-parts":[[2024,11,9]],"date-time":"2024-11-09T09:40:11Z","timestamp":1731145211000},"page":"1-8","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Roles of probiotics against <scp>HPV<\/scp> through the gut\u2010vaginal axis"],"prefix":"10.1002","volume":"169","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-0841-6152","authenticated-orcid":false,"given":"Pei","family":"Xu","sequence":"first","affiliation":[{"name":"Bioprocess Technology, School of Industrial Technology Universiti Sains Malaysia  Gelugor Penang Malaysia"},{"name":"Faculty of Cuisine Sichuan Tourism University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uma 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