{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T15:12:44Z","timestamp":1747149164427,"version":"3.40.5"},"reference-count":25,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,11,14]],"date-time":"2024-11-14T00:00:00Z","timestamp":1731542400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Gynecology &amp; Obste"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To assess the safety of fertility\u2010sparing treatments for early\u2010stage ovarian cancer in women younger than 40\u2009years old.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We performed a retrospective multicenter study including women aged 18\u201340\u2009years diagnosed with early\u2010stage (FIGO I\u2013II) ovarian cancer in 55 Spanish hospitals, from January 2010 to December 2019. Benign and borderline tumors were excluded, as well as advanced stages (FIGO III\u2013IV). All perioperative characteristics and follow\u2010up data were collected and analyzed. Standard staging surgery (SSS) was compared with fertility\u2010sparing surgery (FSS) in terms of oncological outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In all, 366 women were included; 327 (89.3%) were stage I. Among all patients, 216 (59%) underwent SSS and 150 (41%) FSS. Up to 208 (56.8%) patients did not have children, but only 12 (3.2%) had oocyte preservation before treatment. Patients in the FSS group compared with the SSS group showed a non\u2010significant difference in recurrences (8% vs. 9.3%, respectively; <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.711) and deaths (1.3% vs. 4.8%, respectively; <jats:italic>P<\/jats:italic>\u2009=\u20090.211) during the follow\u2010up. No significant differences were found between epithelial and non\u2010epithelial ovarian cancer both in recurrences (7.1% vs. 8.8%, respectively; <jats:italic>P<\/jats:italic>\u2009=\u20090.771) and in deaths (1.4% vs. 1.3%, respectively; <jats:italic>P<\/jats:italic>\u2009=\u20091) among patients who underwent FSS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>FSS seems a safe option for treatment of early\u2010stage ovarian cancer in patients who want to preserve fertility, either for epithelial and non\u2010epithelial histology.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ijgo.16026","type":"journal-article","created":{"date-parts":[[2024,11,14]],"date-time":"2024-11-14T12:37:46Z","timestamp":1731587866000},"page":"163-170","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Oncological safety of fertility preservation treatment in ovarian cancer: A Spanish multicenter 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