{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T15:42:23Z","timestamp":1777045343054,"version":"3.51.4"},"reference-count":25,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,11,25]],"date-time":"2024-11-25T00:00:00Z","timestamp":1732492800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81502255"],"award-info":[{"award-number":["81502255"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Gynecology &amp; Obste"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>This study aimed to assess the value of a HPV E6\/E7 mRNA assay (Aptima\u00ae HPV [AHPV]) for primary cervical cancer screening combined with menopausal status.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 16\u2009917 women underwent AHPV testing and had complete histopathological results at the Affiliated Hospital of Jining Medical University China between January 1, 2017 and March 31, 2022. We evaluated the performance of different screening strategies and combined strategies, as well as evaluations of different menopausal states.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>When identifying LSIL+ (includes low\u2010 and high\u2010grade squamous intraepithelial lesions and invasive cervical cancer [ICC]), the sensitivity (91.2%) and negative predictive value (NPV; 96.6%) were significantly higher for AHPV than for liquid\u2010based cytology assay (LBC; 33.2% and 84.7% for sensitivity and NPV, respectively). Furthermore, the co\u2010testing strategy (cytology combined with AHPV), when compared with AHPV, achieved a slightly higher sensitivity (93.6% vs. 91.2%, respectively, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001), a similar specificity (61.3% vs. 62.7%, respectively, <jats:italic>P<\/jats:italic>\u2009=\u20090.014), a similar positive predictive value (PPV; 37.5% vs. 37.8%, respectively, <jats:italic>P<\/jats:italic>\u2009=\u20090.709) and a similar NPV (97.5% vs. 96.6%, respectively, <jats:italic>P<\/jats:italic>\u2009=\u20090.001). Moreover, AHPV (when compared with menopausal women) achieved a higher sensitivity (93.5% vs. 77.7%, respectively, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001), a higher NPV (97.3% vs. 93.9%, respectively, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001), a similar PPV (37.8% vs. 37.0%, respectively, <jats:italic>P<\/jats:italic>\u2009=\u20090.618) and a slightly lower specificity (60.7% vs. 72.1%, respectively, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001) in premenopausal women. These results were similar when identifying HSIL+ (includes high\u2010grade squamous intraepithelial lesion and ICC).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The present study suggests that initial screening with HPV E6\/E7 mRNA testing rather than combined screening is a suitable candidate for cervical cancer screening in China (especially for premenopausal women) based on economic reasons.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ijgo.16043","type":"journal-article","created":{"date-parts":[[2024,11,25]],"date-time":"2024-11-25T10:42:12Z","timestamp":1732531332000},"page":"215-223","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["<scp>HPV E6<\/scp>\/<scp>E7 mRNA<\/scp> screening alone can be used as a screening method for cervical cancer in premenopausal women in China: A retrospective study"],"prefix":"10.1002","volume":"169","author":[{"given":"Ying","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Gynecology Affiliated Hospital of Jining Medical University  Jining Shandong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shirong","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Gynecology Affiliated Hospital of Jining Medical University  Jining Shandong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yingying","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Gynecology Affiliated Hospital of Jining Medical University  Jining Shandong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yingying","family":"Gong","sequence":"additional","affiliation":[{"name":"Department of Gynecology Affiliated Hospital of Jining Medical University  Jining Shandong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beibei","family":"Du","sequence":"additional","affiliation":[{"name":"Department of Gynecology Affiliated Hospital of Jining Medical University  Jining Shandong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yunfei","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Gynecology Peking University Shenzhen Hospital  Shenzhen Guangdong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-7192-2587","authenticated-orcid":false,"given":"Linqing","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Gynecology Affiliated Hospital of Jining Medical University  Jining Shandong China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,11,25]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jncc.2022.02.002"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.23736\/S0026-4784.19.04397-1"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2019.0298"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2014.11.076"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/1471-0528.12272"},{"key":"e_1_2_11_7_1","volume-title":"WHO Guidelines for Screening and Treatment of Precancerous Lesions for Cervical Cancer Prevention","author":"World Health Organization","year":"2021"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2022.909223"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-016-2893-x"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/LGT.0000000000000393"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2022.935071"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2020.533253"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2018.12.028"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.4103\/joc.joc_42_22"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmi.2021.04.031"},{"issue":"9","key":"e_1_2_11_16_1","first-page":"1734","article-title":"Assessment of cervical cancer molecular\u2010based screening tools; HPV\u2010DNA detection versus E6\/E7 mRNA testing; first report of a prospective cohort study among Iranian women","volume":"49","author":"Mousavi AS","year":"2020","journal-title":"Iran J Public Health"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2021.03.047"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcv.2015.10.027"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(10)70230-8"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1309\/AJCPLCD8TTOMLJTB"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1309\/AJCPZ5JY6FCVNMOT"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1309\/AJCPGW1V2BBWMOCX"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.21147\/j.issn.1000-9604.2020.06.05"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.32861"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1097\/LGT.0000000000000525"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1097\/LGT.0000000000000529"}],"container-title":["International Journal of Gynecology &amp; Obstetrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijgo.16043","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,2]],"date-time":"2025-04-02T08:40:10Z","timestamp":1743583210000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1002\/ijgo.16043"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,25]]},"references-count":25,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,4]]}},"alternative-id":["10.1002\/ijgo.16043"],"URL":"https:\/\/doi.org\/10.1002\/ijgo.16043","archive":["Portico"],"relation":{},"ISSN":["0020-7292","1879-3479"],"issn-type":[{"value":"0020-7292","type":"print"},{"value":"1879-3479","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,11,25]]},"assertion":[{"value":"2024-07-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-11-11","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-11-25","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}