{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T07:04:55Z","timestamp":1781766295252,"version":"3.54.5"},"reference-count":40,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,11,23]],"date-time":"2024-11-23T00:00:00Z","timestamp":1732320000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100019783","name":"Agen\u021bia Na\u021bional\u0103 pentru Cercetare \u0219i Dezvoltare","doi-asserted-by":"publisher","award":["21gk0110047h0003"],"award-info":[{"award-number":["21gk0110047h0003"]}],"id":[{"id":"10.13039\/100019783","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Gynecology &amp; Obste"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Antiphospholipid antibodies (aPL) are recognized to have a pivotal role in recurrent pregnancy loss (RPL) and cardiovascular disease. Therefore, we assessed the vascular function of women with RPL and examined the association with each type of aPL.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this retrospective study, 569 women with RPL and 55 healthy women who had never experienced pregnancy loss were recruited. We performed blood tests for aPL and acceleration plethysmography (APG) to evaluate peripheral vascular function.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The differential pulse wave index (DPI), indicating vascular elasticity, was significantly lower in women with RPL (115.6\u2009\u00b1\u20094.1) compared to the control group (117.0\u2009\u00b1\u20092.3). DPI in RPL women with anti\u2010\u03b2<jats:sub>2<\/jats:sub> glycoprotein I (a\u03b2<jats:sub>2<\/jats:sub>GPI) IgG was significantly lower than those without. Remained blood volume (RBV), indicating post\u2010vasoconstriction blood content, was significantly higher in RPL women with a\u03b2<jats:sub>2<\/jats:sub>GI IgG than in those without. Regression analysis showed a\u03b2<jats:sub>2<\/jats:sub>GPI IgG and body mass index (BMI) linked negatively with DPI.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Women with RPL have subclinical vascular dysfunction even at reproductive age. It is possible that a\u03b2<jats:sub>2<\/jats:sub>GPI IgG is associated with vascular dysfunction in RPL women.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ijgo.16051","type":"journal-article","created":{"date-parts":[[2024,11,23]],"date-time":"2024-11-23T09:56:26Z","timestamp":1732355786000},"page":"206-214","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Vascular dysfunction in women with recurrent pregnancy loss: Possible association with antiphospholipid antibodies"],"prefix":"10.1002","volume":"169","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-8071-355X","authenticated-orcid":false,"given":"Titi","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Okayama University  Okayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emi","family":"Okada","sequence":"additional","affiliation":[{"name":"Graduate School of Health Sciences Okayama University  Okayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maho","family":"Todoroki","sequence":"additional","affiliation":[{"name":"Graduate School of Health Sciences Okayama University  Okayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siyu","family":"Liu","sequence":"additional","affiliation":[{"name":"Graduate School of Health Sciences Okayama University  Okayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rukmali","family":"Athurupana","sequence":"additional","affiliation":[{"name":"Graduate School of Health Sciences Okayama University  Okayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kumie","family":"Kataoka","sequence":"additional","affiliation":[{"name":"Graduate School of Health Sciences Okayama University  Okayama Japan"},{"name":"Reproduction Center Okayama University Hospital  Okayama Japan"},{"name":"Faculty of Health Sciences Okayama University  Okayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiaki","family":"Kashino","sequence":"additional","affiliation":[{"name":"Reproduction Center Okayama University Hospital  Okayama Japan"},{"name":"Department of Obstetrics and Gynecology Okayama University Hospital  Okayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Mitsui","sequence":"additional","affiliation":[{"name":"Reproduction Center Okayama University Hospital  Okayama Japan"},{"name":"Department of Obstetrics and Gynecology Okayama University Hospital  Okayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toru","family":"Hasegawa","sequence":"additional","affiliation":[{"name":"Reproduction Center Okayama University Hospital  Okayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuhiko","family":"Kamada","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Okayama University  Okayama Japan"},{"name":"Reproduction Center Okayama University Hospital  Okayama Japan"},{"name":"Department of Obstetrics and Gynecology Okayama University Hospital  Okayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hisashi","family":"Masuyama","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Okayama University  Okayama Japan"},{"name":"Department of Obstetrics and Gynecology Okayama University Hospital  Okayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0359-4516","authenticated-orcid":false,"given":"Mikiya","family":"Nakatsuka","sequence":"additional","affiliation":[{"name":"Graduate School of Health Sciences Okayama University  Okayama Japan"},{"name":"Reproduction Center Okayama University Hospital  Okayama Japan"},{"name":"Faculty of Health Sciences Okayama University  Okayama Japan"},{"name":"Department of Obstetrics and Gynecology Okayama University Hospital  Okayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,11,23]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/hropen\/hoy004"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/jog.14083"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2004.12.018"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.2004.02497.x"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1999.tb07661.x"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1191\/0961203304lu2001oa"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)50596-2"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1078\/0171-2985-00212"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/17.1.190"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006250-200308000-00020"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.7863\/jum.2003.22.1.27"},{"key":"e_1_2_10_13_1","first-page":"123","volume-title":"Vascular dysfunction in women with recurrent pregnancy loss","author":"Nakatsuka M","year":"2012"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.2010.202226"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jstrokecerebrovasdis.2016.12.018"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.0000251522.18094.d4"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12016-012-8316-0"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajhp\/56.20.2038"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1080\/10409230903193307"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-0378(92)90002-L"},{"issue":"4","key":"e_1_2_10_21_1","first-page":"171","article-title":"Cardiac manifestations of the antiphospholipid antibody syndrome: a review","volume":"99","author":"Nayak AK","year":"2002","journal-title":"Mo Med"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.2174\/1874609811306010010"},{"key":"e_1_2_10_23_1","first-page":"681","article-title":"Classification of acceleration plethysmogram using self\u2010organizing map","volume":"2006","author":"Nousou N","year":"2006","journal-title":"International Symposium on Intelligent Signal Processing and Communications"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.32.2.365"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1253\/circj.70.304"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1186\/1880-6805-32-17"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.2174\/157340312801215782"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1186\/1475-925X-13-139"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1016936206694"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.4258\/hir.2015.21.2.111"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004210100520"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.humrep.a135811"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006250-200108000-00010"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-2275(20)31631-X"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.M600414-JLR200"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12016-008-8096-8"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kem040"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11926-010-0144-8"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11926-013-0324-4"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjhyper.2004.10.009"},{"issue":"4","key":"e_1_2_10_41_1","first-page":"229","article-title":"Prevention of cardiovascular diseases: role of exercise, dietary interventions, obesity and smoking cessation","volume":"10","author":"Buttar HS","year":"2005","journal-title":"Exp Clin Cardiol"}],"container-title":["International Journal of Gynecology &amp; Obstetrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijgo.16051","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,2]],"date-time":"2025-04-02T08:36:46Z","timestamp":1743583006000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1002\/ijgo.16051"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,23]]},"references-count":40,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,4]]}},"alternative-id":["10.1002\/ijgo.16051"],"URL":"https:\/\/doi.org\/10.1002\/ijgo.16051","archive":["Portico"],"relation":{},"ISSN":["0020-7292","1879-3479"],"issn-type":[{"value":"0020-7292","type":"print"},{"value":"1879-3479","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,11,23]]},"assertion":[{"value":"2024-05-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-11-11","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-11-23","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}