{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T14:37:06Z","timestamp":1790087826514,"version":"4.0.1"},"reference-count":26,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,11,30]],"date-time":"2024-11-30T00:00:00Z","timestamp":1732924800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Gynecology &amp; Obste"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate the efficacy of topical chitosan powder in reducing postoperative vaginal bleeding following a loop electrosurgical excision procedure (LEEP).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this randomized controlled trial, patients who underwent LEEP were randomly assigned (1:1) to the chitosan group, in which the wound area was sprayed with chitosan powder using a spray pump, or the control group. The primary outcome was the median quantity of vaginal blood lost in the early postoperative period (defined as within 6\u2009h of the procedure).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The 124 women enrolled in the study were randomly divided into control (<jats:italic>n<\/jats:italic>\u2009=\u200961) and chitosan (<jats:italic>n<\/jats:italic>\u2009=\u200963) groups. The median amount of vaginal blood loss during the early postoperative period was significantly lower in the chitosan group than in the control group (198.85 [64.4\u2013388.57] mL vs. 250.60 [67.7\u2013552.87] mL; <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001). The rate of late postoperative bleeding requiring hemostatic intervention was also lower in the chitosan group than in the control group (3.2% vs. 16.4%; <jats:italic>P<\/jats:italic>\u2009=\u20090.013). Superior cervical wound healing in the chitosan group compared to the control group was also observed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The application of chitosan powder to the cervical wound bed can improve surgical outcomes by decreasing post\u2010LEEP vaginal bleeding and facilitating the healing of cervical wounds.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ijgo.16055","type":"journal-article","created":{"date-parts":[[2024,11,30]],"date-time":"2024-11-30T09:44:45Z","timestamp":1732959885000},"page":"240-246","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Efficacy of chitosan powder in reducing vaginal bleeding following a loop electrosurgical excision procedure: A randomized control 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