{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T11:45:23Z","timestamp":1791805523141,"version":"4.3.4"},"reference-count":55,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,11,30]],"date-time":"2024-11-30T00:00:00Z","timestamp":1732924800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Gynecology &amp; Obste"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>In the present study, a bidirectional two\u2010sample Mendelian randomization approach was utilized to explore potential causal relationships between mitochondrial DNA copy number (mtDNA\u2010CN) and ovary\u2010related reproductive disorders (ORRDs), including ovarian dysfunction, ovarian cyst, polycystic ovary syndrome (PCOS), premature ovarian failure (POF) and ovarian endometriosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Genetic associations with mtDNA\u2010CN were obtained from three genome\u2010wide association study (GWAS) summary statistics from the UK Biobank, and ORRD data were investigated using summary statistics from the FinnGen cohort. Single nucleotide polymorphisms (SNPs) correlated with mtDNA\u2010CN were selected as genetic instrumental variables (IVs) to estimate the causal effect of mtDNA\u2010CN on ORRDs using the inverse\u2010variance weighted (IVW) method with heterogeneity and pleiotropy analysis, and we repeated this in the opposite direction using instruments for ORRDs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      We found that the genetically predicted mtDNA was indicative of increased levels of PCOS (OR\u2009=\u20091.16;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001) and ovarian endometriosis (OR\u2009=\u20091.25;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.007) in the IVW analysis and was not associated with the risk of other ORRDs. In the reverse direction, genetically predicted ORRDs were not associated with mtDNA\u2010CN levels in the IVW analysis. Sensitivity and replication analyses showed the results to be stable.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>We found that mtDNA\u2010CN may increase the risk of PCOS and ovarian endometriosis. This may have implications for mtDNA\u2010CN as a biomarker for these conditions in clinical practice.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ijgo.16057","type":"journal-article","created":{"date-parts":[[2024,11,30]],"date-time":"2024-11-30T04:38:55Z","timestamp":1732941535000},"page":"112-120","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["The mitochondrial\n                    <scp>DNA<\/scp>\n                    copy number and ovary\u2010related reproductive disorders: A bidirectional two\u2010sample Mendelian randomization study"],"prefix":"10.1002","volume":"169","author":[{"given":"Ke","family":"Peng","sequence":"first","affiliation":[{"name":"Department of Gynecology, The International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University &amp; Shanghai Key Laboratory of Embryo Original Diseases  Shanghai China"},{"name":"Shanghai Key Laboratory 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