{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T05:26:59Z","timestamp":1784179619415,"version":"3.55.0"},"reference-count":40,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,11,30]],"date-time":"2024-11-30T00:00:00Z","timestamp":1732924800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Gynecology &amp; Obste"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>The study aimed to evaluate the expression of CD44, CD47, interleukin\u20101 (IL\u20101), and tumor necrosis factor alpha (TNF\u2010\u03b1) in immunohistochemically stained (IHS) samples from endometrioid endometrial cancer (EEC) and to examine their correlation with clinicopathologic parameters.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>IHS was used to assess CD44, CD47, IL\u20101, and TNF\u2010\u03b1 expression in 53 EEC samples. Immunostaining was scored as negative (\u2212), slightly positive (+), moderately positive (++), or strongly\/diffuse positive (+++). The prognostic value of these markers was analyzed in relation to clinicopathologic features, including survival.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In endometrial cancer tissues, positivity rates were CD44 (81%), CD47 (81%), TNF\u2010\u03b1 (40.5%), and IL\u20101 (42.9%). Strong and diffuse CD44 staining was associated with improved survival and linked to endocervical invasion and stage. Patients with slightly positive CD47 had significantly higher rates of pelvic and para\u2010aortic lymph node metastases. Strong TNF\u2010\u03b1 staining correlated with grade 3 EEC, while slightly positive IL\u20101 staining was associated with increased endocervical invasion. No significant correlation was found between CD47, IL\u20101, and TNF\u2010\u03b1 expression and survival.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>CD44 and CD47 were positive in most EEC specimens. CD44 expression was the only marker significantly correlated with overall survival and recurrence. TNF\u2010\u03b1 showed a positive correlation with high\u2010grade tumors, and IL\u20101 staining was inversely associated with endocervical invasion. These findings suggest that CD44 is a prognostic marker for survival, while TNF\u2010\u03b1 and IL\u20101 may have indirect prognostic roles in EEC.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ijgo.16071","type":"journal-article","created":{"date-parts":[[2024,11,30]],"date-time":"2024-11-30T09:34:41Z","timestamp":1732959281000},"page":"121-130","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["The prognostic value of tumor microenvironment in endometrioid type endometrial cancer: Effect of <scp>CD44<\/scp> on oncologic outcome"],"prefix":"10.1002","volume":"169","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8219-116X","authenticated-orcid":false,"given":"Zehra Ozturk","family":"Basarir","sequence":"first","affiliation":[{"name":"Department of Gynecologic Oncology Ankara City Hospital  Ankara 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