{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T13:55:40Z","timestamp":1789480540029,"version":"build-2803163510"},"reference-count":25,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,12,4]],"date-time":"2024-12-04T00:00:00Z","timestamp":1733270400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100013238","name":"Faculty of Medicine Siriraj Hospital, Mahidol University","doi-asserted-by":"publisher","award":["R016433016"],"award-info":[{"award-number":["R016433016"]}],"id":[{"id":"10.13039\/501100013238","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Gynecology &amp; Obste"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>This study assessed the prevalence and factors associated with detecting cervical intraepithelial neoplasia grade 2 or higher (CIN2+) via endocervical curettage (ECC) during colposcopy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Between December 2020 and September 2023, a prospective, cross\u2010sectional study involving women with abnormal cervical cancer screening results who underwent colposcopy was conducted. ECC was performed via a Kevorkian endocervical curette following colposcopy\u2010directed biopsy. The exclusion criteria were glandular cytology abnormalities, pregnancy, post\u2010hysterectomy status, and cervical cancer.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The study included 569 women, with a mean age of 41.6\u2009\u00b1\u200911.7\u2009years. Among the participants, 78.9% presented with low\u2010grade cytology, whereas 21.1% presented with high\u2010grade cytology. All of the patients underwent ECC, with 0.4% (two patients) yielding inadequate samples. ECC detected CIN2+ lesions in 11.6% of the patients (95% confidence interval [CI], 9\u201314.3). Univariable analysis revealed that age, menopausal status, history of CIN2+, high\u2010grade cytology, and high\u2010grade colposcopy impression were significant factors for CIN2+ detection by ECC. Multivariable analysis confirmed high\u2010grade cytology as the sole independent factor (adjusted odds ratio [OR], 13.81 [95% CI, 4.60\u201341.42], <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001). ECC added a diagnostic yield of 2.9% (95% CI, 1.5\u20134.3) for detecting CIN2+ lesions missed by colposcopy\u2010directed biopsy. Multivariable analysis demonstrated an independent association between human papillomavirus 16 (HPV\u201016) infection and the additional diagnostic benefit of ECC, with an adjusted odds ratio (OR) of 6.26 (95% CI, 1.49\u201326.23, <jats:italic>P<\/jats:italic>\u2009=\u20090.012).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study highlights the critical role of ECC in detecting CIN2+ lesions, particularly in patients with high\u2010grade cytology or HPV\u201016 positivity.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ijgo.16074","type":"journal-article","created":{"date-parts":[[2024,12,4]],"date-time":"2024-12-04T13:45:09Z","timestamp":1733319909000},"page":"105-111","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Yield of endocervical curettage in detecting cervical intraepithelial neoplasia grade 2 or higher during colposcopy: A prospective, cross\u2010sectional study"],"prefix":"10.1002","volume":"169","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1913-6613","authenticated-orcid":false,"given":"Nida","family":"Jareemit","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, Faculty of Medicine Siriraj Hospital Mahidol University  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lalita","family":"Theerarojanapong","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Somdejprasangkharach XVII Hospital  Suphan Buri Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natthawadee","family":"Laokulrath","sequence":"additional","affiliation":[{"name":"Department of Pathology, Faculty of Medicine Siriraj Hospital Mahidol University  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vuthinun","family":"Achariyapota","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Faculty of Medicine Siriraj Hospital Mahidol University  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khemanat","family":"Khemworapong","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Faculty of Medicine Siriraj Hospital Mahidol University  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sompop","family":"Kuljarasnont","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Faculty of Medicine Siriraj Hospital Mahidol University  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pornporm","family":"Ittiamornlert","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Faculty of Medicine Siriraj Hospital Mahidol University  Bangkok 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