{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T13:14:11Z","timestamp":1792502051262,"version":"4.5.0"},"reference-count":15,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,12,11]],"date-time":"2024-12-11T00:00:00Z","timestamp":1733875200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Gynecology &amp; Obste"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate the predictive ability of serum beta human chorionic gonadotropin (\u03b2hCG) levels and inflammatory markers derived from hemogram parameters in the success of methotrexate (MTX) treatment for tubal ectopic pregnancy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This retrospective study involved the examination of patients diagnosed with tubal ectopic pregnancy and treated with a single dose of MTX at our clinic between 2018 and 2023. The monocyte\u2010to\u2010lymphocyte ratio (MLR), neutrophil\u2010to\u2010lymphocyte ratio (NLR), platelet\u2010to\u2010lymphocyte ratio (PLR), and systemic immune\u2010inflammation index (SII) were calculated from blood samples taken at the time of presentation. \u03b2hCG levels were recorded on days 1, 4, and 7 of treatment. The patients were categorized into successful and unsuccessful treatment groups based on their response to MTX.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>No statistically significant differences were found between the two groups regarding MLR, NLR, PLR, or SII values (<jats:italic>P<\/jats:italic>\u2009=\u20090.284, <jats:italic>P<\/jats:italic>\u2009=\u20090.097, <jats:italic>P<\/jats:italic>\u2009=\u20090.455, and <jats:italic>P<\/jats:italic>\u2009=\u20090.061, respectively). In the receiver operating characteristic analysis of serum \u03b2hCG from day 1 to day 4, the area under the curve value was calculated as 0.832. The cutoff value for the serum \u03b2hCG change from days 1 to 4 was \u22120.093 (\u22129.3%), with a sensitivity of 85.53% and specificity of 74.14%, and a positive predictive value (PPV) of 87.5%.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>There were no significant differences in inflammatory markers (MLR, NLR, PLR, and SII) between the successful and unsuccessful MTX treatment groups. The change in serum \u03b2hCG levels between days 1 and 4 can be used as an early predictor of MTX treatment success in tubal ectopic pregnancy.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ijgo.16084","type":"journal-article","created":{"date-parts":[[2024,12,11]],"date-time":"2024-12-11T14:11:05Z","timestamp":1733926265000},"page":"639-644","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["The role of inflammatory markers and \u03b2hCG levels in predicting the success of single\u2010dose methotrexate treatment in tubal ectopic pregnancy"],"prefix":"10.1002","volume":"169","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1496-3732","authenticated-orcid":false,"given":"Zekiye","family":"Soykan Sert","sequence":"first","affiliation":[{"name":"Department of Gynecology and Obstetrics Aksaray University Medical School  Aksaray Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1557-5774","authenticated-orcid":false,"given":"Mete","family":"Bertizlio\u011flu","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Konya City Hospital  Konya Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,12,11]]},"reference":[{"issue":"41","key":"e_1_2_10_2_1","first-page":"693","article-title":"The diagnosis and treatment of ectopic pregnancy","volume":"112","author":"Taran FA","year":"2015","journal-title":"Dtsch Arztebl Int"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0000000000002499"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006250-200304000-00028"},{"issue":"10","key":"e_1_2_10_5_1","first-page":"599","article-title":"Ectopic pregnancy: diagnosis and management","volume":"101","author":"Hendriks E","year":"2020","journal-title":"Am Fam Physician"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(22)02478-3"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dml012"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0000000000002560"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1080\/01443615.2016.1174821"},{"issue":"1","key":"e_1_2_10_10_1","first-page":"25","article-title":"Neutrophil\u2010lymphocyte ratio and platelet\u2010lymphocyte ratio on the prediction of methotrexate treatment success in tubal ectopic pregnancy","volume":"6","author":"Do\u011fru HY","year":"2016","journal-title":"J Contemp Med"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.33696\/Gynaecology.4.039"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijgo.15696"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dead089"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2017.06.020"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijgo.12419"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12884-020-03350-8"}],"container-title":["International Journal of Gynecology &amp; Obstetrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijgo.16084","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,21]],"date-time":"2025-04-21T15:09:43Z","timestamp":1745248183000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1002\/ijgo.16084"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,11]]},"references-count":15,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,5]]}},"alternative-id":["10.1002\/ijgo.16084"],"URL":"https:\/\/doi.org\/10.1002\/ijgo.16084","archive":["Portico"],"relation":{},"ISSN":["0020-7292","1879-3479"],"issn-type":[{"value":"0020-7292","type":"print"},{"value":"1879-3479","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,12,11]]},"assertion":[{"value":"2024-08-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-11-30","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-12-11","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}