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The analysis focused on the incremental cost\u2010effectiveness ratio of different treatment regimens.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>C\u2010reactive protein, leukocyte count, and NLR were found to be statistically significant markers for diagnosing TOA. Out of 907 PID cases, 705 achieved clinical cure with initial treatment. The most cost\u2010effective treatment for mild PID without TOA was ceftriaxone combined with azithromycin, which was considered less costly and more effective in the cost\u2010effectiveness analysis. For severe PID with TOA, ampicillin combined with gentamicin and clindamycin was more cost\u2010effective compared to ampicillin with sulbactam plus doxycycline, given a willingness\u2010to\u2010pay threshold of US$213.57 for a 4.2% increase in cure rate.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The study's findings support the use of CRP, leukocyte count, and NLR as diagnostic tools for TOA. Ceftriaxone combined with azithromycin is recommended as the first\u2010line treatment for mild PID at our institution due to its cost\u2010effectiveness. For TOA, ampicillin combined with gentamicin and clindamycin is a cost\u2010effective option if the healthcare system's willingness to pay exceeds US$213.57 for a 4.2% increase in cure rate, contributing valuable insights for PID treatment strategies from a hospital's perspective. The average time of hospital admission for TOA was 3\u2009days. 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