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In view of the large use of such practice, we aimed to assess the literature evidence supporting the use of prophylactic HPV vaccines after diagnosis or treatment of HPV\u2010related gynecologic cancers. Women who develop HPV\u2010related cervical, vaginal, and vulvar cancers represent a subgroup of patients who may be particularly sensitive to HPV infection and re\u2010acquire infections. The rationale that the use of prophylactic HPV vaccination at the time or after treatment for cervical, vaginal, and vulvar cancers might reduce the risk of future HPV\u2010related diseases might be explained by the data coming from the use of HPV vaccination after treatment of pre\u2010invasive disease; however, the evidence on the use of HPV vaccination in the setting of HPV\u2010related gynecologic cancers is currently absent. In this context, observational and experimental studies document an important drop in effectiveness of HPV vaccination by age. Physicians should be aware of catch\u2010up programs in their countries and should be ready to counsel patients about prophylactic HPV vaccine efficacy according to their age. In general, no evidence exists supporting the use of prophylactic HPV vaccine in patients diagnosed with HPV\u2010related gynecologic cancers; therefore, the European Society of Gynecological Oncology (ESGO) prevention committee opinion is to counsel these patients as any HPV\u2010related non\u2010gynecologic cancer (such as anal or oropharyngeal cancer) and non\u2010cancer patient, suggesting vaccination according to patient's age and prognosis, knowing there is a decrease of efficacy with increasing age. Studies on the use of prophylactic HPV vaccine in patients diagnosed with HPV\u2010related gynecologic cancers are strongly needed.<\/jats:p>","DOI":"10.1002\/ijgo.16120","type":"journal-article","created":{"date-parts":[[2024,12,30]],"date-time":"2024-12-30T08:13:45Z","timestamp":1735546425000},"page":"597-604","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Prophylactic <scp>HPV<\/scp> vaccination in <scp>HPV<\/scp>\u2010related gynecologic cancers: European Society of Gynecological Oncology (<scp>ESGO<\/scp>) prevention committee opinion"],"prefix":"10.1002","volume":"169","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1727-904X","authenticated-orcid":false,"given":"Nicol\u00f2","family":"Bizzarri","sequence":"first","affiliation":[{"name":"UOC Ginecologia Oncologica, Dipartimento di Scienze Della Salute Della Donna, del Bambino e di Sanit\u00e0 Pubblica Fondazione Policlinico Universitario Agostino Gemelli 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