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This paper explores the potential of low\u2010dose calcium supplementation as an alternative strategy to the conventional high\u2010dose regimen in preventing pre\u2010eclampsia. A consistent association between low serum calcium levels and an increased risk of pre\u2010eclampsia is established based on studies spanning Ghana, Nigeria, and Ethiopia. The challenges associated with implementing high\u2010dose calcium supplementation, including cost, logistics, limited information, and adherence issues, underscore the need for a paradigm shift. The evidence presented advocates for integrating low\u2010dose calcium supplementation into sub\u2010Saharan African prenatal care programs. The paper emphasizes the role of healthcare providers in educating women about the benefits and safety of low\u2010dose calcium supplements. Future research and implementation initiatives are urged to refine and tailor these approaches to the region's diverse needs, advancing the collective goal of enhancing maternal and newborn health. This exploration of creative and context\u2010specific solutions underscores the potential of low\u2010dose calcium to significantly contribute to reducing the prevalence of hypertensive disorders in pregnancy, particularly pre\u2010eclampsia, ultimately contributing to healthier and thriving communities in sub\u2010Saharan Africa.<\/jats:p>","DOI":"10.1002\/ijgo.16143","type":"journal-article","created":{"date-parts":[[2025,1,13]],"date-time":"2025-01-13T11:52:57Z","timestamp":1736769177000},"page":"1006-1011","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Optimizing pre\u2010eclampsia prevention: Embracing low\u2010dose calcium in sub\u2010Saharan Africa"],"prefix":"10.1002","volume":"169","author":[{"given":"Emmanuel","family":"Kokori","sequence":"first","affiliation":[{"name":"Department of Medicine and Surgery University of Ilorin  Ilorin Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gbolahan","family":"Olatunji","sequence":"additional","affiliation":[{"name":"Department of Medicine and Surgery University of Ilorin  Ilorin Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosemary","family":"Komolafe","sequence":"additional","affiliation":[{"name":"Department of Medicine and Surgery University of Ilorin  Ilorin Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Doyin","family":"Olatunji","sequence":"additional","affiliation":[{"name":"Department of Health Sciences Western Illinois University  Macomb Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ibukunoluwa","family":"Ogunbowale","sequence":"additional","affiliation":[{"name":"Department of Medicine Babcock University Teaching Hospital  Ogun Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Owolabi","family":"Samuel","sequence":"additional","affiliation":[{"name":"Department of Medicine Lagos State Health Service Commission  Lagos Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chidiogo","family":"Ezenwoba","sequence":"additional","affiliation":[{"name":"College of Medicine and Health Sciences Afe Babalola University Ado\u2010Ekiti  Ekiti Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bonaventure","family":"Ukoaka","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Asokoro District Hospital  Abuja Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusuf Ismaila","family":"Ajayi","sequence":"additional","affiliation":[{"name":"Department of Medicine and Surgery Obafemi Awolowo University Ife  Ife Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas","family":"Aderinto","sequence":"additional","affiliation":[{"name":"Department of Medicine Ladoke Akintola University of Technology  Ogbomoso Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,1,13]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0079116"},{"issue":"4","key":"e_1_2_12_3_1","first-page":"2276","article-title":"Maternal and neonatal outcomes of pre\u2010eclampsia in African black women, south West Nigeria","volume":"5","author":"Adeosun OG","year":"2015","journal-title":"Greener J Med Sci"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.2147\/IJWH.S47056"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1155\/2011\/481095"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)60279-6"},{"key":"e_1_2_12_7_1","volume-title":"WHO Recommendation: Calcium Supplementation during Pregnancy for the Prevention of Pre\u2010Eclampsia and its Complications","author":"World Health Organization","year":"2018"},{"key":"e_1_2_12_8_1","volume-title":"Guideline: Calcium Supplementation in Pregnant Women","author":"World Health Organization","year":"2013"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/nyas.14733"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.2147\/CIA.S157523"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2022-070677"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu2050505"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13063-021-05811-7"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD001059.pub4"},{"issue":"1","key":"e_1_2_12_15_1","first-page":"61","article-title":"International maternal\u2010fetal medicine units network (IMMUNE) and calcium for preeclampsia prevention (CPEP) investigators. 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