{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T07:32:52Z","timestamp":1776756772861,"version":"3.51.2"},"reference-count":26,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,2,17]],"date-time":"2025-02-17T00:00:00Z","timestamp":1739750400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100009592","name":"Beijing Municipal Science and Technology Commission, Adminitrative Commission of Zhongguancun Science Park","doi-asserted-by":"publisher","award":["Z131107002213090"],"award-info":[{"award-number":["Z131107002213090"]}],"id":[{"id":"10.13039\/501100009592","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009592","name":"Beijing Municipal Science and Technology Commission, Adminitrative Commission of Zhongguancun Science Park","doi-asserted-by":"publisher","award":["Z191100006619050"],"award-info":[{"award-number":["Z191100006619050"]}],"id":[{"id":"10.13039\/501100009592","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100019871","name":"Beijing Obstetrics and Gynecology Hospital, Capital Medical University","doi-asserted-by":"publisher","award":["fcyy201613"],"award-info":[{"award-number":["fcyy201613"]}],"id":[{"id":"10.13039\/501100019871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100019871","name":"Beijing Obstetrics and Gynecology Hospital, Capital Medical University","doi-asserted-by":"publisher","award":["YQRC201905"],"award-info":[{"award-number":["YQRC201905"]}],"id":[{"id":"10.13039\/501100019871","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Gynecology &amp; Obste"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate the relationship of leiomyoma characteristics with perinatal outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective cohort study was conducted. Women whose pregnancy was complicated with leiomyoma were recruited, and pregnant women without leiomyomas were enrolled as a control group. Demographic data, leiomyoma ultrasound characteristics, and pregnancy outcomes were collected. Subsequently, antepartum, intrapartum, postpartum, and neonatal complications were analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The overall rate of leiomyomas in pregnancy was 5.46% (4393\/80510). Out of the 932 pregnancies studied, 632 were affected by leiomyoma. Women with leiomyomas exhibited significantly higher age, pre\u2010pregnancy BMI, gravidity, and in\u00a0vitro fertilization\u2010embryo transfer rate. The occurrence of antepartum, intrapartum, and postpartum complications was influenced by different features of leiomyomas. Among leiomyoma with diameter of 9\u2009cm or greater, cervical or submucous types were detrimental. In the multivariate linear regression analyses, a leiomyoma with diameter of at least 9\u2009cm during pregnancy was independently associated with preterm birth, cesarean section, preterm premature rupture of membranes, and postpartum hemorrhage.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The presence of leiomyoma of 9\u2009cm or more increases the risk of antepartum, intrapartum, and postpartum complications; therefore, pre\u2010conception myomectomy can be considered. For leiomyoma 7\u20139\u2009cm, extensive discussions between patients and clinicians should be conducted. In women with leiomyomas smaller than 7\u2009cm, the risk of obstetric complications is similar to that in women without leiomyomas, except for those with cervical or submucous leiomyomas.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ijgo.16159","type":"journal-article","created":{"date-parts":[[2025,2,17]],"date-time":"2025-02-17T10:25:10Z","timestamp":1739787910000},"page":"388-400","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Association between leiomyoma characteristics and perinatal complications: A retrospective cohort study"],"prefix":"10.1002","volume":"170","author":[{"given":"Yu\u2010Cui","family":"Tian","sequence":"first","affiliation":[{"name":"Department of Perinatal Medicine Beijing Obstetrics and Gynecology Hospital, Capital Medical University. Beijing Maternal and Child Health Care Hospital  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin","family":"Ding","sequence":"additional","affiliation":[{"name":"Department of Perinatal Medicine Beijing Obstetrics and Gynecology Hospital, Capital Medical University. Beijing Maternal and Child Health Care Hospital  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian\u2010Hong","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Gynecology Beijing Obstetrics and Gynecology Hospital, Capital Medical University. Beijing Maternal and Child Health Care Hospital  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hai\u2010Xia","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Intensive Care Unit Juye Country People's Hospital  Juye China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1765-5137","authenticated-orcid":false,"given":"Yin\u2010Mei","family":"Dai","sequence":"additional","affiliation":[{"name":"Department of Gynecology Beijing Obstetrics and Gynecology Hospital, Capital Medical University. 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