{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T14:37:14Z","timestamp":1787236634933,"version":"build-2736575974"},"reference-count":31,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,1,24]],"date-time":"2025-01-24T00:00:00Z","timestamp":1737676800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Gynecology &amp; Obste"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The objective of this paper is to study the association between obesity and tumor recurrence in patients with vulvar cancer.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This is a retrospective study including vulvar cancer patients from 2003 to 2022. Our primary outcome was progression\u2010free survival (PFS) stratified by status of obesity, defined as body mass index (BMI) &gt;30.0\u2009kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Overall, 48 patients were included in the study, with 32 (66.7%) diagnosed at early stages (I\u2013II). The median BMI was 28.0\u2009kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      [interquartile range 24.9\u201332.3\u2009kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      ]. There were 13 obese patients (27%), and the median follow\u2010up time was 55\u2009months [interquartile range 14\u2013102]. Most patients (80%) were HPV\u2010independent of human papilloma virus. Surgical intervention was the primary treatment modality for 88% (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200942) of the cohort, and 26 patients (54%) received adjuvant chemoradiation. Disease recurrence was identified in 28 patients (58%). The median PFS was 68\u2009months, and the median overall survival was 109\u2009months. There was no difference in the median PFS between obese patients and non\u2010obese patients (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.370). In a Cox regression analysis, after adjusting for patient age, margin\u2010free distance, and stage of disease, BMI was not associated with PFS hazard ratio 1.06 (0.99\u20131.12).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Obesity is not associated with PFS in patients with vulvar cancer, and BMI might not be considered a risk factor for recurrence.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ijgo.16182","type":"journal-article","created":{"date-parts":[[2025,1,25]],"date-time":"2025-01-25T02:34:53Z","timestamp":1737772493000},"page":"268-273","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Association between body mass index, obesity, and vulvar cancer recurrence"],"prefix":"10.1002","volume":"170","author":[{"given":"Yossi","family":"Tzur","sequence":"first","affiliation":[{"name":"Division of Gynecologic Oncology Jewish General Hospital, McGill University  Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Magri","sequence":"additional","affiliation":[{"name":"School of Medicine McGill University  Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raanan","family":"Meyer","sequence":"additional","affiliation":[{"name":"Division of Minimally Invasive Gynecologic Surgery, Department of Obstetrics and Gynecology, Cedars Sinai Medical Center  California Los Angeles USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melica Nourmoussavi","family":"Brodeur","sequence":"additional","affiliation":[{"name":"Division of Gynecologic Oncology Jewish General Hospital, McGill University  Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shannon","family":"Salvador","sequence":"additional","affiliation":[{"name":"Division of Gynecologic Oncology Jewish General Hospital, McGill University  Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susie","family":"Lau","sequence":"additional","affiliation":[{"name":"Division of Gynecologic Oncology Jewish General Hospital, McGill University  Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Walter","family":"Gotlieb","sequence":"additional","affiliation":[{"name":"Division of Gynecologic Oncology Jewish General Hospital, McGill University  Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1282-5379","authenticated-orcid":false,"given":"Gabriel","family":"Levin","sequence":"additional","affiliation":[{"name":"Division of Gynecologic Oncology Jewish General Hospital, McGill University  Montreal Quebec Canada"},{"name":"The Department of Gynecologic Oncology, Hadassah Medical Center, Faculty of Medicine Hebrew University of Jerusalem  Jerusalem Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,1,24]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21834"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijgo.13881"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/cnr2.2120"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.3389\/ijph.2022.1605021"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/GME.0000000000001687"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/hpm.3383"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2023.10.014"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1525-1438.2002.01105.x"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2008.05.001"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00404-024-07537-8"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMsa1909301"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2022.155217"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jit297"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0019092"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1136\/ijgc-2019-001187"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.6004\/jnccn.2024.0013"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijgo.13880"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2021.3520"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers15020485"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/dju426"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-med-121211-091527"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1249\/MSS.0000000000001937"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu14163329"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmwh.2009.10.001"},{"issue":"4","key":"e_1_2_10_26_1","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1097\/SAP.0000000000003808","article-title":"The effect of obesity on Vaginoplasty outcomes","volume":"92","author":"Berger LE","year":"2024","journal-title":"Ann Plast Surg"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2023.08.002"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1080\/0284186X.2023.2197124"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1097\/CEJ.0000000000000164"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1177\/2053369117709225"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2015.10.020"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2016.03.035"}],"container-title":["International Journal of Gynecology &amp; Obstetrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijgo.16182","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,19]],"date-time":"2025-06-19T01:38:33Z","timestamp":1750297113000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1002\/ijgo.16182"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,24]]},"references-count":31,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,7]]}},"alternative-id":["10.1002\/ijgo.16182"],"URL":"https:\/\/doi.org\/10.1002\/ijgo.16182","archive":["Portico"],"relation":{},"ISSN":["0020-7292","1879-3479"],"issn-type":[{"value":"0020-7292","type":"print"},{"value":"1879-3479","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1,24]]},"assertion":[{"value":"2024-12-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-01-13","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-01-24","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}