{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,20]],"date-time":"2025-06-20T04:06:32Z","timestamp":1750392392101,"version":"3.41.0"},"reference-count":15,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T00:00:00Z","timestamp":1740096000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Gynecology &amp; Obste"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Ewing sarcoma is an aggressive, rare bone and soft tissue malignancy, often affecting the long bones and pelvis. A woman was diagnosed with Ewing sarcoma of the left pelvis at 18\u2009years of age. She underwent left paravesical lesion resection with ipsilateral ureteral reimplantation and received combined multi\u2010agent chemotherapy and high\u2010dose pelvic radiotherapy. A gonadotropin\u2010releasing hormone analog was administered to preserve ovarian function. The patient received oral contraceptives as hormone replacement therapy due to secondary amenorrhea. She spontaneously conceived after the withdrawal of oral contraceptives at 24\u2009years. The pregnancy was complicated by early third\u2010trimester impaired fetal growth and preterm premature rupture of membranes at 32\u2009weeks of pregnancy. Spontaneous preterm labor started and the patient delivered vaginally at 34\u2009weeks, without any complications. Including our report, only 10 cases of pregnancy after pelvic Ewing sarcoma are reported in the literature. Pregnancy and delivery can be achieved after combined pelvic treatment for Ewing sarcoma, taking into account possible obstetric risks and complications. Complex bone surgery is associated with cesarean delivery, but previous high\u2010dose pelvic irradiation does not seem to affect mode of delivery. Our report provides further information on perinatal management, given the cases previously described.<\/jats:p>","DOI":"10.1002\/ijgo.70029","type":"journal-article","created":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T11:07:48Z","timestamp":1740136068000},"page":"164-168","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Spontaneous conception and pregnancy outcomes after multi\u2010agent chemotherapy and high\u2010dose radiotherapy for pelvic Ewing sarcoma: Case report and literature review"],"prefix":"10.1002","volume":"170","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6228-3390","authenticated-orcid":false,"given":"Valentina","family":"Tosto","sequence":"first","affiliation":[{"name":"Obstetrics and Gynecology Unit IRCCS Istituto Giannina Gaslini  Genoa Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7793-714X","authenticated-orcid":false,"given":"Federico","family":"Prefumo","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynecology Unit IRCCS Istituto Giannina Gaslini  Genoa Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7503-0034","authenticated-orcid":false,"given":"Carolina","family":"Scala","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynecology Unit IRCCS Istituto Giannina Gaslini  Genoa Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-9458-8851","authenticated-orcid":false,"given":"Ramona","family":"Tallone","sequence":"additional","affiliation":[{"name":"D.O.P.O. 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