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After the exclusion of papers published in languages other than English and experimental studies in animals, 340 studies were considered eligible. Studies with medicines other than corticosteroids, misoprostol, and nifedipine were removed, leaving a total of 240 articles. From the remaining records, 24 reports were not retrieved. The research strategy allowed the final identification of 76 references.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Off\u2010label drug use in obstetrics has transitioned from being an exception to a routine, scientifically validated practice. While its application is justified by clinical outcomes and international protocols, healthcare providers must navigate a strict framework of ethical and legal responsibility.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ijgo.70076","type":"journal-article","created":{"date-parts":[[2025,3,23]],"date-time":"2025-03-23T11:17:18Z","timestamp":1742728638000},"page":"568-575","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Off\u2010label use of drugs in pregnancy: A critical review of guidelines, current practices, and a clinical perspective"],"prefix":"10.1002","volume":"170","author":[{"given":"Vitalba","family":"Gallitelli","sequence":"first","affiliation":[{"name":"Division of Gynecology and Obstetrics Hospital Isola Tiberina Gemelli Isola  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rita","family":"Franco","sequence":"additional","affiliation":[{"name":"Division of 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