{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,20]],"date-time":"2026-06-20T04:54:11Z","timestamp":1781931251032,"version":"3.54.5"},"reference-count":51,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,4,15]],"date-time":"2025-04-15T00:00:00Z","timestamp":1744675200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Gynecology &amp;amp; Obste"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>BRCA1\/2 mutation carriers have a lifetime ovarian cancer risk of 40%\u201345% for BRCA1 and 15%\u201320% for BRCA2. The most effective risk\u2010reduction strategy for women with known BRCA mutations remains bilateral risk\u2010reducing salpingo\u2010oophorectomy (RRSO), which reduces the risk by 80%. The primary objective of this study is to assess the long\u2010term incidence of primary peritoneal carcinoma (PPC) following RRSO and to evaluate the occurrence of premalignant and malignant lesions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This retrospective cohort study followed BRCA1\/2\u2010positive patients who underwent RRSO, using data from two medical centers in Haifa Israel between 2002 and 2023. Data collected included demographic characteristics and pathology results post\u2010surgery. Outcomes included rates of occult cancer (OC), serous tubal intraepithelial carcinoma (STIC), and PPC.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 214 women underwent RRSO. Of these, 126 (58.8%) had a BRCA1 mutation, 76 (35.5%) had a BRCA2 mutation, and 12 (5.6%) carried both BRCA1 and BRCA2 mutations. During a mean follow\u2010up of 122.4\u2009months (SD\u2009\u00b1\u200984.0), three patients (1.5%) developed PPC. OC was identified in 13 patients (6.1%) during RRSO. Out of the 13 OC patients, eight (61.5%) were classified as stage 1. The overall survival for the OC population was 117.2\u2009\u00b1\u200955.9\u2009months. STIC was detected in two patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In this large retrospective analysis of BRCA carriers who underwent RRSO, we confirmed that long\u2010term follow\u2010up is crucial for BRCA mutation carriers undergoing RRSO, as malignancies can still arise over time. In our study, the incidence of PPC was 1.5%, highlighting the need for extended surveillance. These findings underscore the importance of meticulous surgical protocols, expert pathology review, and ongoing monitoring to optimize patient outcomes.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ijgo.70110","type":"journal-article","created":{"date-parts":[[2025,4,15]],"date-time":"2025-04-15T08:04:36Z","timestamp":1744704276000},"page":"1188-1198","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Pathology results of risk\u2010reducing salpingo\u2010oophorectomy in <scp>BRCA1<\/scp>\/2 carriers and long\u2010term clinical outcomes"],"prefix":"10.1002","volume":"170","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2866-9457","authenticated-orcid":false,"given":"Wisam","family":"Assaf","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, Lady Davis Carmel Medical Center Technion University, Rappaport Faculty of Medicine  Haifa Israel"},{"name":"Rappaport Faculty of Medicine Technion\u2010Israel Institution of Technology  Haifa Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amalfi","family":"Qarawani","sequence":"additional","affiliation":[{"name":"Rappaport Faculty of Medicine Technion\u2010Israel Institution of Technology  Haifa Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yousef","family":"Abboud","sequence":"additional","affiliation":[{"name":"Rappaport Faculty of Medicine Technion\u2010Israel Institution of Technology  Haifa Israel"},{"name":"Department of Obstetrics and Gynecology, Rambam Health Care Campus Technion University, Rappaport Faculty of Medicine  Haifa Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eiman","family":"Shalabna","sequence":"additional","affiliation":[{"name":"Rappaport Faculty of Medicine Technion\u2010Israel Institution of Technology  Haifa Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Nahshon","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Lady Davis Carmel Medical Center Technion University, Rappaport Faculty of Medicine  Haifa Israel"},{"name":"Rappaport Faculty of Medicine Technion\u2010Israel Institution of Technology  Haifa Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ariel","family":"Zilberlicht","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Lady Davis Carmel Medical Center Technion University, Rappaport Faculty of Medicine  Haifa Israel"},{"name":"Rappaport Faculty of Medicine Technion\u2010Israel Institution of Technology  Haifa Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ari","family":"Reiss","sequence":"additional","affiliation":[{"name":"Rappaport Faculty of Medicine Technion\u2010Israel Institution of Technology  Haifa Israel"},{"name":"Department of Obstetrics and Gynecology, Emek Medical Center, Rappaport Faculty of Medicine Technion University  Haifa Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meirav","family":"Schmidt","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Lady Davis Carmel Medical Center Technion University, Rappaport Faculty of Medicine  Haifa Israel"},{"name":"Rappaport Faculty of Medicine Technion\u2010Israel Institution of Technology  Haifa Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yakir","family":"Segev","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Lady Davis Carmel Medical Center Technion University, Rappaport Faculty of Medicine  Haifa Israel"},{"name":"Rappaport Faculty of Medicine Technion\u2010Israel Institution of Technology  Haifa Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,4,15]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.29210"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21332"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.5858\/2000-124-474-TOTOMG"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1086\/318787"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1997.03540360065034"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2006.09.1066"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djt095"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1053\/ob.1996.v175.a74288"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-143-5-200509060-00011"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.7326\/M13-2747"},{"issue":"6","key":"e_1_2_10_12_1","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1001\/jama.1995.03520300065039","article-title":"NIH consensus conference. 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