{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T18:29:48Z","timestamp":1757615388666,"version":"3.44.0"},"reference-count":23,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,4,17]],"date-time":"2025-04-17T00:00:00Z","timestamp":1744848000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012023","name":"Stichting Sanquin Bloedvoorziening","doi-asserted-by":"publisher","award":["PPOC\u201011\u2010032"],"award-info":[{"award-number":["PPOC\u201011\u2010032"]}],"id":[{"id":"10.13039\/501100012023","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Gynecology &amp;amp; Obste"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>The aim of this study was to compare the cost of a strategy initially resorting to intrauterine balloon tamponade versus a strategy initially resorting to uterine artery embolization in the management pathway of persistent postpartum hemorrhage.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a propensity score\u2013matched cohort study including women who were subsequently treated with (scenario 1) versus uterine artery embolization (scenario 2) in order to control PPH, defined as postpartum bleeding that was resistant to first\u2010line treatment.<\/jats:p><jats:p>We compared these two scenarios in terms of cost. These were based on costs of intervention, blood products transfused, and intensive care unit admission. We calculated the mean cost difference between the scenarios per woman.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The propensity score\u2013matched cohort comprised 50 women per scenario. In scenario 1, intrauterine balloon tamponade was successful in 29 women (58%), with a mean cost per patient of \u20ac7060 (standard deviation [SD], \u20ac2846). In scenario 2, uterine artery embolization was successful in 42 women (84%), with mean cost per patient of \u20ac7122 (SD, \u20ac2918). In each scenario, six women (12%) underwent a peripartum hysterectomy. The difference in mean cost per woman between the two scenarios was \u20ac62 in favor of scenario 1.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>There is a negligible difference in cost between scenarios in which women with PPH are initially managed with intrauterine balloon tamponade versus uterine artery embolization. Given the comparable cost and maternal outcomes, intrauterine balloon tamponade is a favorable treatment, considering its less invasive nature, practical considerations, and lower risk of complications.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ijgo.70149","type":"journal-article","created":{"date-parts":[[2025,4,17]],"date-time":"2025-04-17T10:53:07Z","timestamp":1744887187000},"page":"1337-1345","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Cost analysis of intrauterine balloon tamponade versus uterine artery embolization in the management of persistent postpartum hemorrhage"],"prefix":"10.1002","volume":"170","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2846-6243","authenticated-orcid":false,"given":"Lisanne R.","family":"Bonsen","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Leiden University Medical Center  Leiden the Netherlands"},{"name":"Department of Clinical Epidemiology Leiden University Medical Center  Leiden the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. Elske","family":"van den Akker\u2010van Marle","sequence":"additional","affiliation":[{"name":"Department of Biomedical Data Sciences Section Medical Decision Making, Leiden University Medical Centre  Leiden the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3161-5684","authenticated-orcid":false,"given":"Camila","family":"Caram\u2010Deelder","sequence":"additional","affiliation":[{"name":"Department of Clinical Epidemiology Leiden University Medical Center  Leiden the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9753-3983","authenticated-orcid":false,"given":"Paul I.","family":"Ramler","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Leiden University Medical Center  Leiden the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christianne J. M.","family":"de Groot","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Amsterdam UMC, Universiteit van Amsterdam  Amsterdam the Netherlands"},{"name":"Amsterdam Reproduction and Development Research Institute  Amsterdam the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thijs","family":"Urlings","sequence":"additional","affiliation":[{"name":"Department of Radiology Haaglanden Medical Center  The Hague the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9890-9145","authenticated-orcid":false,"given":"Thomas","family":"van den Akker","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Leiden University Medical Center  Leiden the Netherlands"},{"name":"Athena Institute, VU University  Amsterdam the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9095-2475","authenticated-orcid":false,"given":"Johanna G.","family":"van der Bom","sequence":"additional","affiliation":[{"name":"Department of Clinical Epidemiology Leiden University Medical Center  Leiden the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3164-8611","authenticated-orcid":false,"given":"Dacia D. C. A.","family":"Henriquez","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Leiden University Medical Center  Leiden the Netherlands"},{"name":"Department of Clinical Epidemiology Leiden University Medical Center  Leiden the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"the TeMpOH\u20101 study group","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,4,17]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2214-109X(14)70227-X"},{"volume-title":"WHO Recommendations for the Prevention and Treatment of Postpartum Haemorrhage","year":"2012","key":"e_1_2_11_3_1"},{"volume-title":"WHO Recommendation on Tranexamic Acid for the Treatment of Postpartum Haemorrhage","year":"2017","key":"e_1_2_11_4_1"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/1471-0528.16040"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm12237471"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijgo.14116"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0000000000002351"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/1471-0528.14178"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD013663"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2019.11.1287"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/aogs.13679"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/s42155-020-00174-7"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2012.08.028"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/aogs.13130"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0187555"},{"key":"e_1_2_11_17_1","unstructured":"World Health Organisation.Evaluating the quality of care for severe pregnancy complications: the WHO near\u2010miss approach for maternal health.2011Accessed February 2 2022.http:\/\/apps.who.int\/iris\/bitstream\/10665\/44692\/1\/9789241502221_eng.pdf."},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/1471-0528.15335"},{"issue":"3","key":"e_1_2_11_19_1","first-page":"299","article-title":"Understanding the costs of surgery: a bottom\u2010up cost analysis of both a hybrid operating room and conventional operating room","volume":"11","author":"Patel S","year":"2022","journal-title":"Int J Health Policy Manag"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000207583"},{"volume-title":"Costing Manual for Economic Evaluations in Healthcare: Methodology and Reference Prices","year":"2024","author":"Hakkaart\u2010van Roijen L","key":"e_1_2_11_21_1"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/1471-0528.16819"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0000000000004674"},{"volume-title":"Methods for the Economic Evaluation of Health Care Programmes","year":"2015","author":"Drummond MF","key":"e_1_2_11_24_1"}],"container-title":["International Journal of Gynecology &amp; Obstetrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijgo.70149","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,5]],"date-time":"2025-09-05T14:31:06Z","timestamp":1757082666000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1002\/ijgo.70149"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,17]]},"references-count":23,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,9]]}},"alternative-id":["10.1002\/ijgo.70149"],"URL":"https:\/\/doi.org\/10.1002\/ijgo.70149","archive":["Portico"],"relation":{},"ISSN":["0020-7292","1879-3479"],"issn-type":[{"type":"print","value":"0020-7292"},{"type":"electronic","value":"1879-3479"}],"subject":[],"published":{"date-parts":[[2025,4,17]]},"assertion":[{"value":"2024-08-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-03-27","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-04-17","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}