{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T11:33:14Z","timestamp":1783078394676,"version":"3.54.6"},"reference-count":21,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,4,12]],"date-time":"2025-04-12T00:00:00Z","timestamp":1744416000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,4,12]],"date-time":"2025-04-12T00:00:00Z","timestamp":1744416000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YFC2702503"],"award-info":[{"award-number":["2022YFC2702503"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Gynecology &amp;amp; Obste"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>This study aimed to evaluate the efficiency of endometrial receptivity testing (ERT) in improving pregnancy outcomes for patients with recurrent implantation failure (RIF), and to investigate the incidence of implantation window displacement.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Conducted between April 2021 and August 2022, at a university\u2010affiliated reproductive center, the study included 85 RIF patients who had failed to achieve pregnancy after three embryo transfers. As part of a multicenter prospective cohort study (ChiCTR2200059342), 45 patients underwent ERT\u2010guided frozen single blastocyst transfer, while 40 received standard treatment without ERT. Endometrial preparation was performed using a hormone replacement therapy (HRT) protocol in the cycle preceding transfer. Endometrial sampling for ERT, including RNA sequencing, artificial intelligence, and discriminant analysis of endometrial receptivity, was conducted on day 5 after progesterone administration to determine the implantation window. The same HRT protocol was used in the transfer cycle, with embryo transfer timed according to the ERT\u2010calculated window.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Our data showed that 28.07% of patients exhibited a displaced implantation window, all characterized by pre\u2010receptive endometrium. The ERT group had significantly higher clinical pregnancy rates (57.78% vs. 35.00%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.036) and live birth rates (53.33% vs. 30.00%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.030) compared with the non\u2010ERT group.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our findings suggest that approximately one\u2010third of RIF occurrences may be due to endometrial factors, and ERT\u2010guided personalized embryo transfer significantly improves pregnancy outcomes, underscoring its value in reproductive medicine.<\/jats:p>\n                  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