{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:43:24Z","timestamp":1786977804397,"version":"build-2736575974"},"reference-count":41,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,4,21]],"date-time":"2025-04-21T00:00:00Z","timestamp":1745193600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,4,21]],"date-time":"2025-04-21T00:00:00Z","timestamp":1745193600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Gynecology &amp;amp; Obste"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The aim of the study was to evaluate age\u2010 and body mass index (BMI, calculated as weight in kilograms divided by the square of height in meters)\u2010related changes in hormonal profile in women with PCOS and to compare hormonal changes among women with polycystic ovary syndrome (PCOS) with and without infertility.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      In this case\u2013control study, conducted from March 2018 to January 2024, we enrolled women with PCOS with infertility (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009265) and controls (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009265) matched for age and BMI at the Department of Endocrinological Gynecology in University Hospital, Krakow, Poland. The assessment of anti\u2010M\u00fcllerian hormone (AMH) along with hormonal profile including follicle\u2010stimulating hormone (FSH), luteinizing hormone (LH), estradiol (E\n                      <jats:sub>2<\/jats:sub>\n                      ), androgens (testosterone, 17\u2010hydroxyprogesterone [17\u2010OHP], dehydroepiandrosterone sulfate [DHEA\u2010S]) as well as sex\u2010hormone binding globulin was performed among these women, after assignment to different age BMI groups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Women with POCS and infertility showed higher AMH (+42.9%), E\n                      <jats:sub>2<\/jats:sub>\n                      (+15.9%) and LH (+41.9%) along with increased androgen levels reflected by increased testosterone (+20%), DHEA\u2010S (+28.7%) and lower FSH (\u221210.3%) in contrary to women without infertility. Younger women (\u226425\u2009years) showed higher AMH, LH and androgens levels (total testosterone and DHEA\u2010S) with lower FSH concentration. Women with higher BMI (\u226530) had lower AMH together with increased free androgen index (FAI) and decreased sex hormone binding globulin (SHBG).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Infertile women with PCOS represent higher AMH together with elevated total testosterone, DHEA\u2010S and FAI levels in contrary to fertile ones. Higher BMI together with older age have a negative impact on AMH in women with PCOS.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ijgo.70160","type":"journal-article","created":{"date-parts":[[2025,4,21]],"date-time":"2025-04-21T10:40:18Z","timestamp":1745232018000},"page":"353-361","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Age and\n                    <scp>BMI<\/scp>\n                    \u2010related changes in hormonal profile in women with polycystic ovary syndrome (\n                    <scp>PCOS<\/scp>\n                    ): Association with infertility"],"prefix":"10.1002","volume":"171","author":[{"given":"Ewa","family":"Zabieg\u0142o","sequence":"first","affiliation":[{"name":"Gynecological Endocrinology Department Jagiellonian University Medical College  Krakow 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