{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T17:07:07Z","timestamp":1772989627423,"version":"3.50.1"},"reference-count":35,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,4,19]],"date-time":"2025-04-19T00:00:00Z","timestamp":1745020800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,4,19]],"date-time":"2025-04-19T00:00:00Z","timestamp":1745020800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Gynecology &amp;amp; Obste"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The French College of Obstetricians and Gynecologists has decided to update its clinical practices guidelines for preventing RhD alloimmunization in the first trimester of pregnancy. The quality of evidence of the literature was assessed following the GRADE methodology with questions formulated in the Patients, Intervention, Comparison, Outcome (PICO) format and outcomes defined a priori and classified according to their importance. An extensive bibliographic search was performed using Pubmed, Cochrane, EMBASE, and Google Scholar databases. The quality of evidence was assessed (high, moderate, low, very low) and a recommendation was formulated: strong, weak, or no recommendation. The recommendations were reviewed in two rounds by members of the scientific board of the French College of Obstetricians and Gynecologists (Delphi survey) in order to select the consensus recommendations. The three recommendations from the PICO questions were agreed upon through the use of the Delphi method. It is not recommended to administer RhD immune globulin before 12\u2009weeks of gestation to reduce the risk of alloimmunization in the event of induced or spontaneous abortion in RhD\u2010negative patients when the progenitor is RhD\u2010positive or unknown (weak recommendation, very low\u2010quality evidence). It is not recommended to administer RhD immune globulin before 12\u2009weeks of gestation to reduce the risk of alloimmunization in the event of bleeding (weak recommendation, very low\u2010quality evidence). The quality and quantity of literature data are insufficient to determine whether injection of RhD immune globulin can reduce the risk of alloimmunization in ectopic pregnancy, so no recommendation could be made.<\/jats:p>","DOI":"10.1002\/ijgo.70166","type":"journal-article","created":{"date-parts":[[2025,4,19]],"date-time":"2025-04-19T04:02:56Z","timestamp":1745035376000},"page":"63-71","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Prevention of\n                    <scp>RhD<\/scp>\n                    alloimmunization in the first trimester of pregnancy: Clinical practice guidelines of the French College of Obstetricians and Gynecologists"],"prefix":"10.1002","volume":"171","author":[{"given":"Paul","family":"Maurice","sequence":"first","affiliation":[{"name":"National Reference Center for Perinatal Hemobiology, Armand Trousseau Hospital AP\u2010HP. Sorbonne Universit\u00e9  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sol\u00e8ne","family":"Vigoureux","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynecology Department CHU Nantes  Nantes France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charles","family":"Garabedian","sequence":"additional","affiliation":[{"name":"Department of Obstetrics Jeanne de Flandre Hospital, CHU Lille  France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeanne","family":"Sibiude","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynecology Department, Armand Trousseau Hospital AP\u2010HP. 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