{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T17:06:53Z","timestamp":1772989613038,"version":"3.50.1"},"reference-count":61,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,5,9]],"date-time":"2025-05-09T00:00:00Z","timestamp":1746748800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,5,9]],"date-time":"2025-05-09T00:00:00Z","timestamp":1746748800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Gynecology &amp;amp; Obste"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Gynecological surgery is generally associated with a high risk of postoperative nausea and vomiting (PONV), for which a combination of antiemetic therapies is advised, but adherence to these protocols is often low. Given the current reality, a preferred 5\u2010HT\n                      <jats:sub>3<\/jats:sub>\n                      receptor antagonist for preventing PONV as a result of gynecological operations might be desirable. However, the efficiency of different 5\u2010HT\n                      <jats:sub>3<\/jats:sub>\n                      receptor antagonists in gynecological operations was not clear.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>\n                      To assess the effectiveness of different 5\u2010HT\n                      <jats:sub>3<\/jats:sub>\n                      antagonists in preventing PONV after gynecological surgery.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Search Strategy<\/jats:title>\n                    <jats:p>Electronic databases, including PubMed, Embase, the Cochrane Library, and Web of Science, were searched for randomized clinical trials (RCTs) from their inception up to September 20, 2023.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Selection Criteria<\/jats:title>\n                    <jats:p>\n                      Patients who received only 5\u2010HT\n                      <jats:sub>3<\/jats:sub>\n                      antagonists to prevent nausea and vomiting following gynecologic surgical procedures were included. Only RCT articles and English language literature were included.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Data Collection and Analysis<\/jats:title>\n                    <jats:p>Two investigators independently assessed the study quality and performed data extraction. R software and STATA 17 were used for this network meta\u2010analysis to compare treatments using a frequentist approach.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Main Results<\/jats:title>\n                    <jats:p>Palonosetron demonstrated superior efficacy compared with ondansetron, with a significant difference in \u201cacute nausea,\u201d \u201coverall nausea,\u201d \u201cacute vomiting,\u201d \u201clate vomiting,\u201d \u201clate PONV,\u201d \u201coverall PONV,\u201d \u201clate rescue medicine\u201d and \u201c&gt;24\u2009h rescue medicine.\u201d There was a significant difference between palonosetron and ramosetron in \u201cacute nausea,\u201d between ramosetron and ondansetron in \u201c&gt;24\u2009h nausea,\u201d and between granisetron and ondansetron in \u201clate vomiting.\u201d Additionally, granisetron and palonosetron are generally ranked higher in the P\u2010score system.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In gynecological surgery, palonosetron demonstrated superior efficacy to ondansetron. Granisetron seemed to be the most effective alternative to palonosetron in our study.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ijgo.70197","type":"journal-article","created":{"date-parts":[[2025,5,9]],"date-time":"2025-05-09T10:55:32Z","timestamp":1746788132000},"page":"177-189","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["5\u2010\n                    <scp>\n                      HT\n                      <sub>3<\/sub>\n                    <\/scp>\n                    receptor antagonists for preventing postoperative nausea and vomiting after gynecological surgery: A systematic review and network meta\u2010analysis"],"prefix":"10.1002","volume":"171","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-6591-4348","authenticated-orcid":false,"given":"Hongxia","family":"Xu","sequence":"first","affiliation":[{"name":"Department of Clinical Pharmacy Wendeng Hospital of Traditional Chinese Orthopedics and Traumatology of Shandong Province  Weihai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lingyan","family":"Rong","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy Wendeng Hospital of Traditional Chinese Orthopedics and Traumatology of Shandong Province  Weihai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shaohui","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy Wendeng Hospital of Traditional Chinese Orthopedics and Traumatology of Shandong Province  Weihai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiankun","family":"Xing","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy Wendeng Hospital of Traditional Chinese Orthopedics and Traumatology of Shandong Province  Weihai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huajun","family":"Dong","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy Wendeng Hospital of Traditional Chinese Orthopedics and Traumatology of Shandong Province  Weihai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huihui","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy Wendeng Hospital of Traditional Chinese Orthopedics and Traumatology of Shandong Province  Weihai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaotao","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy Wendeng Hospital of Traditional Chinese Orthopedics and Traumatology of Shandong Province  Weihai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lingyan","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy Wendeng Hospital of Traditional Chinese Orthopedics and Traumatology of Shandong Province  Weihai China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,5,9]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2044.2002.02822.x"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0000000000004833"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2044.2000.055002163.x"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/71.4.517"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12871-017-0357-8"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.5114\/aoms.2019.83293"},{"issue":"2","key":"e_1_2_10_8_1","first-page":"53","article-title":"The observance of evidence\u2010based guidelines for the prevention of postoperative nausea and vomiting is difficult in daily practice of an academic hospital\u2010a retrospective cohort study","volume":"70","author":"Dusart CC","year":"2019","journal-title":"Acta Anaesthesiol Belg"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/EJA.0b013e32834a3d81"},{"issue":"1","key":"e_1_2_10_10_1","first-page":"9","article-title":"PONV prophylaxis failure disproportionately affects female patients, despite intraoperative computerized decision support guidance","volume":"2","author":"Krieser KA","year":"2020","journal-title":"Grad Med Educ"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0000000000006509"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1517\/14656566.2015.1033398"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bja.2017.08.003"},{"key":"e_1_2_10_14_1","first-page":"313","article-title":"The effect of requesting a reason for non\u2010adherence to a guideline in a long running automated reminder system for PONV prophylaxis","volume":"8","author":"Kooij FO","year":"2017","journal-title":"Appl Clin Inform"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000031155"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1080\/01443615.2020.1789961"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0000000000006251"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-6576.2006.01171.x"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF03018236"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinane.2016.05.018"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1177\/0300060517715374"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12871-015-0102-0"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12871-016-0210-5"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aep209"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.4103\/1658-354X.125917"},{"key":"e_1_2_10_26_1","unstructured":"HigginsJPT GreenS.Cochrane Handbook for Systematic Reviews of Interventions Version 5.3.5.2014The Cochrane Collaboration. Accessed August 2018.www.handbook.cochrane.org"},{"issue":"1","key":"e_1_2_10_27_1","first-page":"490","article-title":"Comparative study of efficacy and safety of ondansetron and Ramosetron in patients undergoing hysterectomy","volume":"15","author":"Patil SB","year":"2023","journal-title":"Int J Pharm Clin Res"},{"issue":"8","key":"e_1_2_10_28_1","first-page":"253","article-title":"A comparative study of Granisetron, palanosetron and ondansetron in post\u2010operative nausea and vomiting after Gynaecological surgery under general Anaesthesia","volume":"14","author":"Bandyopadhyay D","year":"2022","journal-title":"Int J Pharm Clin Res"},{"issue":"9","key":"e_1_2_10_29_1","article-title":"A randomised controlled trial to compare the effect of Ramosetron and ondansetron in prevention of postoperative nausea and vomiting in patients undergoing laparoscopic Gynaecological procedures","volume":"14","author":"Das S","year":"2022","journal-title":"Cureus"},{"issue":"3","key":"e_1_2_10_30_1","article-title":"A randomised study to compare palonosetron with ondansetron for prophylaxis of postoperative nausea and vomiting (PONV) following laparoscopic gynecological surgeries","volume":"14","author":"Balyan R","year":"2022","journal-title":"Cureus"},{"issue":"9","key":"e_1_2_10_31_1","first-page":"977","article-title":"A randomized, double\u2010blind trial of palonosetron compared with ondansetron in preventing postoperative nausea and vomiting after Gynaecological laparoscopic surgery","volume":"14","author":"Yadav M","year":"2022","journal-title":"Int J Pharm Clin Res"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00540-015-1981-4"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.4097\/kjae.2013.64.2.133"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.4097\/kjae.2013.64.2.122"},{"issue":"2","key":"e_1_2_10_35_1","first-page":"165","article-title":"Qualitative comparison of metoclopramide, ondansetron and granisetron alone and in combination with dexamethasone in the prevention of postoperative nausea and vomiting in day care laparoscopic gynaecological surgery under general anaesthesia","volume":"5","author":"Daria U","year":"2012","journal-title":"Asian J Pharm Clin Res"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1177\/147323001103900207"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.4103\/1658-354X.76484"},{"issue":"3","key":"e_1_2_10_38_1","first-page":"303","article-title":"Antiemetic prophylaxis with Granisetron, ondansetron and metoclopramide in ambulatory Gynaecological laparoscopic surgery: a comparison","volume":"24","author":"Bhatia N","year":"2008","journal-title":"J Anaesthesiol Clin Pharmacol"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.3349\/ymj.2010.51.1.88"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1159\/000320747"},{"issue":"11","key":"e_1_2_10_41_1","first-page":"14","article-title":"Comparison of intravenous ondansetron, Ramosetron and palonosetron for prevention of postoperative nausea and vomiting in patients undergoing Total abdominal hysterectomy: a RCT","volume":"15","author":"Tarigonda S","year":"2021","journal-title":"J Clin Diagn Res"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1177\/0310057X9902700506"},{"issue":"3","key":"e_1_2_10_43_1","first-page":"223","article-title":"Low\u2010dose granisetron for the prevention of postoperative nausea and vomiting","volume":"6","author":"Bridges JD","year":"2006","journal-title":"J Appl Secur Res"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.4097\/kjae.2011.61.6.488"},{"issue":"4","key":"e_1_2_10_45_1","first-page":"1570","article-title":"A control, randomized, double blind, fixed dose comparative study to evaluate the efficacy of granisetron, ondansetron and metoclopramide in prevention of post\u2010operative nausea and vomiting in gynecological oncosurgeries","volume":"8","author":"Sumitha CS","year":"2021","journal-title":"Eur J Mol Clin Med"},{"issue":"3","key":"e_1_2_10_46_1","first-page":"UC01","article-title":"Comparative study of ondansetron and palonosetron for prevention of nausea and vomiting following upper abdominal surgeries under general Anaesthesia: a randomised control trial","volume":"14","author":"Gupta DP","year":"2020","journal-title":"J Clin Diagn Res"},{"issue":"1","key":"e_1_2_10_47_1","first-page":"1933","article-title":"An observational study to compare the safety, efficacy and antiemetic effect of intravenous palonosetron, ondansetron and granisetron for prevention of postoperative nausea and vomiting in patients undergoing elective LSCS","volume":"27","author":"Chauhan D","year":"2023","journal-title":"J Clin Otorhinolaryngol Head Neck Surg"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.14260\/jemds\/2020\/35"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.18231\/j.ijca.2020.011"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.26502\/acc.059"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.4236\/ojanes.2020.1010031"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.17085\/apm.2020.15.1.28"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.3390\/jpm13010082"},{"issue":"3","key":"e_1_2_10_54_1","first-page":"44","article-title":"Comparative study on ondansetron with Granisetron in the prevention of postoperative nausea and vomiting in subjects undergoing laparoscopic cholecystectomy under general anesthesia","volume":"5","author":"Taneja P","year":"2021","journal-title":"Acta Sci Pharm Sci"},{"key":"e_1_2_10_55_1","doi-asserted-by":"publisher","DOI":"10.4103\/aihb.aihb_153_20"},{"issue":"1","key":"e_1_2_10_56_1","first-page":"97","article-title":"Comparison of ondansetron and Granisetron in prevention of post\u2010operative nausea and vomiting following laparoscopic cholecystectomy","volume":"17","author":"Saeed R","year":"2023","journal-title":"APMC"},{"key":"e_1_2_10_57_1","doi-asserted-by":"publisher","DOI":"10.4103\/bjoa.bjoa_233_20"},{"key":"e_1_2_10_58_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLE.0b013e31827549e8"},{"key":"e_1_2_10_59_1","first-page":"10","article-title":"Comparison of intravenous Ramosetron and ondansetron as prophylaxis for postoperative nausea and vomiting following general anesthesia","volume":"12","author":"Opneja S","year":"2021","journal-title":"J Pharmacol Pharmacother"},{"issue":"1","key":"e_1_2_10_60_1","first-page":"8","article-title":"Comparison of intravenous Ramosetron and ondansetron for prevention of postoperative nausea and vomiting in patients undergoing laparoscopic surgeries","volume":"3","author":"Fating DR","year":"2018","journal-title":"Acad Anesth Int"},{"key":"e_1_2_10_61_1","doi-asserted-by":"publisher","DOI":"10.1177\/0300060519871171"},{"key":"e_1_2_10_62_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0186006"}],"container-title":["International Journal of Gynecology &amp; Obstetrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijgo.70197","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ijgo.70197","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijgo.70197","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T12:00:09Z","timestamp":1772971209000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1002\/ijgo.70197"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,9]]},"references-count":61,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,10]]}},"alternative-id":["10.1002\/ijgo.70197"],"URL":"https:\/\/doi.org\/10.1002\/ijgo.70197","archive":["Portico"],"relation":{},"ISSN":["0020-7292","1879-3479"],"issn-type":[{"value":"0020-7292","type":"print"},{"value":"1879-3479","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5,9]]},"assertion":[{"value":"2024-05-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-04-22","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-05-09","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}