{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T17:07:23Z","timestamp":1772989643141,"version":"3.50.1"},"reference-count":24,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,5,16]],"date-time":"2025-05-16T00:00:00Z","timestamp":1747353600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,5,16]],"date-time":"2025-05-16T00:00:00Z","timestamp":1747353600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Gynecology &amp;amp; Obste"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Neurofibromatosis Type 1 is a genetic disorder resulting in RAS pathway activation. As a result, risk of developing both benign and malignant neoplasms is higher, compared with the general population. Plexiform neurofibromas are benign tumors of the peripheral nerve sheath affecting 40%\u201350% of patients with neurofibromatosis Type 1. Cervical\u2010parametrial plexiform neurofibroma is a very rare neoplasm. Here we present the ninth case in the literature. A 37\u2010year\u2010old woman presented with chronic pelvic pain and a pelvic mass that was 73\u2009\u00d7\u200933\u2009mm in size. Most of the mass was located between the proximal vagina\u2010cervix and the bladder. It was infiltrating the bilateral parametrium and the pararectal tissues. There was hydronephrosis on the right side and her right kidney was atrophic. The tumor would likely also cause obstruction on the left side. We performed a type B radical hysterectomy, right salpingo\u2010oophorectomy, left salpingectomy, cystoscopy, left ureterorenoscopy, and left ureteral double\u2010j catheterization, in addition to resection of the tumor, which was located between the cervix and bladder. She was followed for 11\u2009months without any tumor relapse. The\u00a0left kidney remained normal in the follow\u2010up period. To our knowledge, this is the first publication reporting the neurofibromatosis Type1 mutation c.7615\u2009+\u20096\u2009T&gt;C as a pathogenic variant. In this case, we showed that plexiform neurofibromas and neurofibromatosis should be taken into account, when a pelvic mass adjacent to the uterine cervix is diagnosed, particularly if the tumor tends to accompany the peripheral nerve tracts. Surgical treatment of cervical\u2010parametrial plexiform neurofibromas is recommended in certain circumstances and a multidisciplinary approach may help to determine the optimal management.<\/jats:p>","DOI":"10.1002\/ijgo.70212","type":"journal-article","created":{"date-parts":[[2025,5,16]],"date-time":"2025-05-16T05:01:18Z","timestamp":1747371678000},"page":"202-206","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Plexiform neurofibroma infiltrating uterine cervix and parametrium, causing hydronephrosis: A case report and review of the literature"],"prefix":"10.1002","volume":"171","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5404-0118","authenticated-orcid":false,"given":"Yasin","family":"Durmu\u015f","sequence":"first","affiliation":[{"name":"Department of Gynecological Oncology Samsun Training and Research Hospital  Samsun T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mustafa Koray","family":"K\u0131rda\u011f","sequence":"additional","affiliation":[{"name":"Department of Urology Samsun Training and Research Hospital  Samsun T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K\u0131van\u00e7","family":"Y\u0131lmaz","sequence":"additional","affiliation":[{"name":"Department of Pathology Samsun Training and Research Hospital  Samsun T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emre","family":"Ayd\u0131n","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Faculty of Medicine Samsun University  Samsun T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mesut","family":"Ozturk","sequence":"additional","affiliation":[{"name":"Department of Radiology, Faculty of Medicine Samsun University  Samsun T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00d6zlem","family":"Sezer","sequence":"additional","affiliation":[{"name":"Department of Medical Genetics, Faculty of Medicine Samsun University  Samsun T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,5,16]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22115850"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2017.4"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/jog.13116"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.39.5.311"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/bcr-2020-236542"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.3350\/cmh.2015.0021"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPH.0000000000000773"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.105.3.608"},{"issue":"5","key":"e_1_2_7_10_1","first-page":"575","article-title":"Conference statement. National Institutes of Health consensus development conference","volume":"45","author":"Neurofibromatosis","year":"1988","journal-title":"Arch Neurol"},{"key":"e_1_2_7_11_1","unstructured":"https:\/\/varsome.com\/variant\/hg19\/NF1%20c.7615%2B6T%3EC?annotation\u2010mode=germlinehttps:\/\/franklin.genoox.com\/clinical\u2010db\/variant\/snp\/chr17\u201029679438\u2010T\u2010C."},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mcna.2019.07.004"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/PGP.0b013e31822b8504"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1447-0756.2011.01816.x"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2008.01.074"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.5858\/2005-129-783-PNOTUC"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/0029-7844(96)00242-6"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(52)90088-4"},{"issue":"1","key":"e_1_2_7_19_1","first-page":"39","article-title":"Neurofibromatosis (Recklinghausen's disease) with gastrointestinal and uterine manifestations: report of a case","volume":"74","author":"Taylor WI","year":"1974","journal-title":"J Am Osteopath Assoc"},{"issue":"2","key":"e_1_2_7_20_1","first-page":"90","article-title":"Neurofibromatosis of the cervix uteri","volume":"31","author":"Char G","year":"1982","journal-title":"West Indian Med J"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-198910000-00007"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1590\/S1677-55382005000200011"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/neuonc\/noac109"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1093\/neuonc\/noac146"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1442-2042.2001.00380.x"}],"container-title":["International Journal of Gynecology &amp; Obstetrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijgo.70212","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ijgo.70212","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijgo.70212","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T12:00:59Z","timestamp":1772971259000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1002\/ijgo.70212"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,16]]},"references-count":24,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,10]]}},"alternative-id":["10.1002\/ijgo.70212"],"URL":"https:\/\/doi.org\/10.1002\/ijgo.70212","archive":["Portico"],"relation":{},"ISSN":["0020-7292","1879-3479"],"issn-type":[{"value":"0020-7292","type":"print"},{"value":"1879-3479","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5,16]]},"assertion":[{"value":"2024-06-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-04-29","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-05-16","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}