{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T15:36:07Z","timestamp":1784302567406,"version":"3.55.0"},"reference-count":25,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T00:00:00Z","timestamp":1747180800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T00:00:00Z","timestamp":1747180800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82470242"],"award-info":[{"award-number":["82470242"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82170301"],"award-info":[{"award-number":["82170301"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005089","name":"Natural Science Foundation of Beijing Municipality","doi-asserted-by":"publisher","award":["L222152"],"award-info":[{"award-number":["L222152"]}],"id":[{"id":"10.13039\/501100005089","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Gynecology &amp;amp; Obste"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>\n                      Placental vascular development is critical for maternal\u2010fetal exchange, and altered fetal cardiovascular physiology in congenital heart disease (CHD) may impact placental circulation. This study aimed to assess whether Slow\n                      <jats:italic>flow<\/jats:italic>\n                      HD imaging technology could qualitatively evaluate alterations in placental vascular structure in CHD.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A cross\u2010sectional study was conducted using Slow\n                      <jats:italic>flow<\/jats:italic>\n                      HD to image placental vasculature in 215 fetuses, normal (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009106) and CHD (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009109) including critical CHD (CCHD) (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200966) and other fetal heart disease (FHD) (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200943). Slow\n                      <jats:italic>flow<\/jats:italic>\n                      HD provided two\u2010dimensional (2D) and three\u2010dimensional (3D) imaging of placental villous tree structures. Differences in display rates and distribution characteristics of placental villous trees were analyzed between the normal, CCHD, and FHD groups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Slow\n                      <jats:italic>flow<\/jats:italic>\n                      HD imaging technology demonstrated high sensitivity in visualizing placental vascular structures, with overall display rates of 95.5%\u2013100%. Primary, secondary, and tertiary villi were visualized with rates of 95.5%\u2013100%, 69.7%\u201397.7%, and 34.8%\u201388.7%, respectively. Four distinct placental villous tree types (types 0\u20133) were identified, exhibiting different distribution characteristics. The composition ratios of these types differed significantly between normal and CCHD fetuses, as well as between CCHD and FHD groups (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      Slow\n                      <jats:italic>flow<\/jats:italic>\n                      HD imaging technology effectively identifies and characterizes placental villous tree structures. Placental villous trees in CCHD fetuses display sparser distribution patterns compared with normal fetuses, highlighting potential implications for maternal\u2010fetal exchange in CHD.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ijgo.70215","type":"journal-article","created":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T10:16:27Z","timestamp":1747217787000},"page":"296-304","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Four novel types of placental villous trees: Insights from\n                    <scp>\n                      Slow\n                      <i>flow<\/i>\n                      HD\n                    <\/scp>\n                    ultrasound imaging into placental microvascular architecture in congenital heart disease"],"prefix":"10.1002","volume":"171","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-0378-7084","authenticated-orcid":false,"given":"Hairui","family":"Wang","sequence":"first","affiliation":[{"name":"Maternal\u2010Fetal Medicine Center in Fetal Heart Disease, Beijing Anzhen Hospital Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xueqin","family":"Ji","sequence":"additional","affiliation":[{"name":"Peking University First Hospital Ningxia Women and Children's Hospital (Ningxia Hui Autonomous Region Maternal and Child Health Hospital)  Yinchuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiancheng","family":"Han","sequence":"additional","affiliation":[{"name":"Maternal\u2010Fetal Medicine Center in Fetal Heart Disease, Beijing Anzhen Hospital Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Wu","sequence":"additional","affiliation":[{"name":"Maternal\u2010Fetal Medicine Center in Fetal Heart Disease, Beijing Anzhen Hospital Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyan","family":"Hao","sequence":"additional","affiliation":[{"name":"Maternal\u2010Fetal Medicine Center in Fetal Heart Disease, Beijing Anzhen Hospital Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaoyang","family":"Xie","sequence":"additional","affiliation":[{"name":"Maternal\u2010Fetal Medicine Center in Fetal Heart Disease, Beijing Anzhen Hospital Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyan","family":"Gu","sequence":"additional","affiliation":[{"name":"Maternal\u2010Fetal Medicine Center in Fetal Heart Disease, Beijing Anzhen Hospital Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Sun","sequence":"additional","affiliation":[{"name":"Maternal\u2010Fetal Medicine Center in Fetal Heart Disease, Beijing Anzhen Hospital Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yihua","family":"He","sequence":"additional","affiliation":[{"name":"Maternal\u2010Fetal Medicine Center in Fetal Heart Disease, Beijing Anzhen Hospital Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,5,14]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1542\/neo.24-9-e569"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-981-19-7696-4_14-1"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.5515"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2022.08.013"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/00001703-199507010-00003"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijgo.15793"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ultrasmedbio.2022.02.012"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/jum.16196"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.29095"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41390-021-01521-7"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.2174\/1573396317666210219162515"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2023.08.068"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/jum.15531"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ultrasmedbio.2021.01.029"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.21037\/qims-22-807"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.22043"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pediatrneurol.2024.03.028"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00246-018-1876-x"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.7863\/ultra.16.04023"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.5791"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtbi.2016.06.037"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2009.11.003"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.20149"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.18839"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.6572"}],"container-title":["International Journal of Gynecology &amp; Obstetrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijgo.70215","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ijgo.70215","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijgo.70215","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T12:00:50Z","timestamp":1772971250000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1002\/ijgo.70215"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,14]]},"references-count":25,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,10]]}},"alternative-id":["10.1002\/ijgo.70215"],"URL":"https:\/\/doi.org\/10.1002\/ijgo.70215","archive":["Portico"],"relation":{},"ISSN":["0020-7292","1879-3479"],"issn-type":[{"value":"0020-7292","type":"print"},{"value":"1879-3479","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5,14]]},"assertion":[{"value":"2025-01-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-04-29","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-05-14","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}