{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,28]],"date-time":"2025-11-28T09:35:18Z","timestamp":1764322518569,"version":"3.46.0"},"reference-count":25,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,5,19]],"date-time":"2025-05-19T00:00:00Z","timestamp":1747612800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002081","name":"Irish Research Council","doi-asserted-by":"publisher","award":["EBPPG\/2021\/38"],"award-info":[{"award-number":["EBPPG\/2021\/38"]}],"id":[{"id":"10.13039\/501100002081","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Gynecology &amp; Obste"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To evaluate the use of the Abbott i\u2010STAT\u00ae1 point\u2010of\u2010care\u2010test (POCT) device for measurement of human chorionic gonadotropin (hCG) to support the management of early pregnancy complications in a remote early pregnancy unit (EPU).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Women attending the EPU who required an hCG blood test were invited to take part in the study. Participants provided an additional blood sample for whole blood hCG measurement using the Abbott i\u2010STAT\u00ae1 analyzer. The remaining sample was sent to the hospital laboratory for hCG analysis using the Abbott Architect, the designated comparator method. Statistical analysis was performed using Analyze\u2010IT software.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 61 women were recruited, including cases of pregnancy of unknown location, ectopic pregnancy, and molar pregnancy. Fourteen hCG results that were outside the i\u2010STAT\u00ae1 assay's quantitative range, although still broadly concordant with laboratory hCG results, were excluded from statistical analysis. Analysis of the remaining 47 paired hCG results demonstrated strong agreement across the concentration range (4\u20132072\u2009IU\/L), with excellent Spearman correlation (\n                      <jats:italic>r<\/jats:italic>\n                      \u2009=\u20090.99,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001). Passing\u2010Bablok linear regression indicated good agreement (\n                      <jats:italic>y<\/jats:italic>\n                      \u2009=\u20091.18\u2009+\u20090.96\n                      <jats:italic>x<\/jats:italic>\n                      ) and Bland\u2013Altman analysis showed a mean difference of \u221223.7\u2009IU\/L (\u22123.5%).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>All hCG results from the i\u2010STAT\u00ae1 analyzer were clinically concordant with the central laboratory method, supporting its application in an EPU setting using established clinical decision thresholds. However, further verification through larger\u2010scale studies is necessary before the i\u2010STAT\u00ae1 analyzer can be integrated into clinical practice.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ijgo.70217","type":"journal-article","created":{"date-parts":[[2025,5,19]],"date-time":"2025-05-19T09:16:23Z","timestamp":1747646183000},"page":"736-742","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Use of the Abbott i\u2010\n                    <scp>STAT<\/scp>\n                    \u00ae1 point of care device for\n                    <scp>hCG<\/scp>\n                    quantification in early pregnancy"],"prefix":"10.1002","volume":"171","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7231-8331","authenticated-orcid":false,"given":"Caroline","family":"Joyce","sequence":"first","affiliation":[{"name":"Pregnancy Loss Research Group, Department of Obstetrics &amp; Gynaecology University College Cork  Cork Ireland"},{"name":"INFANT Research Centre University College Cork  Cork Ireland"},{"name":"Department of Biochemistry &amp; Cell Biology University College Cork  Cork Ireland"},{"name":"Department of Clinical Biochemistry Cork University Hospital  Cork Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9392-1711","authenticated-orcid":false,"given":"Paula M.","family":"O'Shea","sequence":"additional","affiliation":[{"name":"Department of Clinical Biochemistry &amp; Diagnostic Endocrinology The Mater Misericordiae University Hospital  Dublin Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rebecca","family":"Lynch","sequence":"additional","affiliation":[{"name":"Department of Obstetrics &amp; Gynaecology Cork University Maternity Hospital  Cork Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2464-3735","authenticated-orcid":false,"given":"Se\u00e1n J.","family":"Costelloe","sequence":"additional","affiliation":[{"name":"Department of Clinical Biochemistry Cork University Hospital  Cork Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4884-6972","authenticated-orcid":false,"given":"Tommie V.","family":"McCarthy","sequence":"additional","affiliation":[{"name":"Department of Biochemistry &amp; Cell Biology University College Cork  Cork Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Coulter","sequence":"additional","affiliation":[{"name":"Department of Obstetrics &amp; Gynaecology Cork University Maternity Hospital  Cork Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2490-3661","authenticated-orcid":false,"given":"Deirdre","family":"Hayes\u2010Ryan","sequence":"additional","affiliation":[{"name":"Pregnancy Loss Research Group, Department of Obstetrics &amp; Gynaecology University College Cork  Cork Ireland"},{"name":"Department of Obstetrics &amp; Gynaecology Cork University Maternity Hospital  Cork Ireland"},{"name":"National Perinatal Epidemiology Centre University College Cork  Cork Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4616-2887","authenticated-orcid":false,"given":"Keelin","family":"O'Donoghue","sequence":"additional","affiliation":[{"name":"Pregnancy Loss Research Group, Department of Obstetrics &amp; Gynaecology University College Cork  Cork Ireland"},{"name":"INFANT Research Centre University College Cork  Cork Ireland"},{"name":"Department of Obstetrics &amp; Gynaecology Cork University Maternity Hospital  Cork Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,5,19]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rbmo.2023.103643"},{"key":"e_1_2_9_3_1","unstructured":"GranneI HeneghanC PriceCP Van den BruelA PluddemannA.Point\u2010of\u2010Care Testing for Human Chorionic Gonadotrophin (hCG) [Internet]. 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