{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:45:44Z","timestamp":1786977944158,"version":"build-2736575974"},"reference-count":41,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,7,2]],"date-time":"2025-07-02T00:00:00Z","timestamp":1751414400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100017594","name":"Medical Science and Technology Project of Zhejiang Province","doi-asserted-by":"publisher","award":["2019RC121"],"award-info":[{"award-number":["2019RC121"]}],"id":[{"id":"10.13039\/501100017594","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017594","name":"Medical Science and Technology Project of Zhejiang Province","doi-asserted-by":"publisher","award":["2017KY013"],"award-info":[{"award-number":["2017KY013"]}],"id":[{"id":"10.13039\/501100017594","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017594","name":"Medical Science and Technology Project of Zhejiang Province","doi-asserted-by":"publisher","award":["2018KY264"],"award-info":[{"award-number":["2018KY264"]}],"id":[{"id":"10.13039\/501100017594","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004731","name":"Natural Science Foundation of Zhejiang Province","doi-asserted-by":"publisher","award":["LGC22H180002"],"award-info":[{"award-number":["LGC22H180002"]}],"id":[{"id":"10.13039\/501100004731","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Gynecology &amp; Obste"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To evaluate the treatment response in early\u2010onset intrahepatic cholestasis of pregnancy (ICP) and the alterations in the bile acid composition during treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Pregnant women diagnosed with ICP at this institution between January 2020 and December 2021 were screened for enrollment in this prospective cohort. The clinical manifestations, treatment responses, and outcomes of early\u2010 and late\u2010onset ICP were analyzed. The bile acid profile was analyzed using liquid chromatography\u2013tandem mass spectrometry.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Of the 26 ICP patients enrolled, 14 were diagnosed with early\u2010onset (within the first 28\u2009weeks of gestation). There was no significant difference in the serum level of total bile acid (TBA) at diagnosis between early\u2010onset and late\u2010onset ICP, and the TBA level in patients with late\u2010onset ICP was significantly lower than in patients with early\u2010onset ICP after treatment with ursodeoxycholic acid (UDCA) (median, 32.15\u2009\u03bcmol\/L vs. 10.75\u2009\u03bcmol\/L,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.004). The composition of bile acids at diagnosis was comparable between the two groups and changed dramatically in both groups following UDCA treatment. Additionally, significant differences were observed in the bile acid composition between the women with early\u2010onset and late\u2010onset ICP after treatment. Patients with early\u2010onset ICP experienced more adverse pregnancy outcomes compared with those with late\u2010onset ICP (8\/14 vs. 3\/11).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Early\u2010onset ICP demonstrated a distinct response to UDCA treatment, as reflected in a different pattern of bile acid composition. Assessing the bile acid profile might facilitate the identification of high\u2010risk women who do not respond well to UDCA therapy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ijgo.70247","type":"journal-article","created":{"date-parts":[[2025,7,2]],"date-time":"2025-07-02T08:05:04Z","timestamp":1751443504000},"page":"819-827","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Distinct response to treatment and characteristics of bile acid composition of early\u2010 and late\u2010onset intrahepatic cholestasis of pregnancy: A prospective pilot study"],"prefix":"10.1002","volume":"171","author":[{"given":"Yaqing","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Obstetrics, Center for Reproductive Medicine Hangzhou Medical College, Zhejiang Provincial People's Hospital, Affiliated People's Hospital  Hangzhou Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Yao","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Center for Reproductive Medicine Hangzhou Medical College, Zhejiang Provincial People's Hospital, Affiliated People's Hospital  Hangzhou Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiqi","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Center for Reproductive Medicine Hangzhou Medical College, Zhejiang Provincial People's Hospital, Affiliated People's Hospital  Hangzhou Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minqiang","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory, Center for Laboratory Medicine Hangzhou Medical College, Zhejiang Provincial People's Hospital, Affiliated People's Hospital  Hangzhou Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junfa","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Radiology Hangzhou Medical College, Zhejiang Provincial People's Hospital, Affiliated People's Hospital  Hangzhou Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caixia","family":"Qi","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Center for Reproductive Medicine Hangzhou Medical College, Zhejiang Provincial People's Hospital, Affiliated People's Hospital  Hangzhou Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9655-5534","authenticated-orcid":false,"given":"Liwei","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Center for Reproductive Medicine Hangzhou Medical College, Zhejiang Provincial People's Hospital, Affiliated People's Hospital  Hangzhou Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,7,2]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0000000000000346"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.20336"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2008-1078756"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/1471-0528.12174"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.26617"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2014.07.026"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0301-2115(98)00086-4"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13023-021-01887-1"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2018.04.035"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1080\/14767058.2017.1397124"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0176504"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.3390\/medicina55080454"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.14.5781"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijgo.2014.09.013"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/JPN.0000000000000077"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.3906\/sag-1403-7"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.f6055"},{"key":"e_1_2_9_19_1","unstructured":"KenyonAP GirlingJC on behalf ofthe Royal College of Obstetricians and Gynaecologists.Obstetric cholestasis. 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