{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T22:30:03Z","timestamp":1792189803795,"version":"4.4.0"},"reference-count":13,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,5,27]],"date-time":"2025-05-27T00:00:00Z","timestamp":1748304000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Gynecology &amp; Obste"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To evaluate the diagnostic accuracy of hysteroscopic endomyometrial biopsy using Spirotome,complemented by transvaginal ultrasound (TVUS) and magnetic resonance imaging (MRI), for diagnosis of adenomyosis in patients with abnormal uterine bleeding.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A prospective observational study (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200960) was conducted at Ain Shams University Maternity Hospital. Patients underwent TVUS, MRI, and office hysteroscopy\u2010guided biopsy using the Spirotome before hysterectomy. Biopsy results were compared with final pathology.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Biopsy sensitivity (86.36%), specificity (90%), and overall accuracy (87.5%) were recorded. TVUS demonstrated high sensitivity (100%) but low positive predictive value (66.66%). MRI showed sensitivity of 87.5% and specificity of 75%.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study demonstrates the diagnostic efficacy of hysteroscopic endomyometrial biopsy using a Spirotome, complemented by TVUS and MRI, in adenomyosis diagnosis. A sequential diagnostic approach enhances detection rates, improving patient outcomes. Integrating office hysteroscopy\u2010guided biopsy into diagnostic protocols will provide accurate diagnoses and targeted treatments.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ijgo.70253","type":"journal-article","created":{"date-parts":[[2025,5,27]],"date-time":"2025-05-27T06:40:03Z","timestamp":1748328003000},"page":"705-710","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Accuracy of endomyometrial biopsy in diagnosis of adenomyosis: A prospective study"],"prefix":"10.1002","volume":"171","author":[{"given":"Mohamed","family":"Laban","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, Faculty of Medicine, Ain Shams Maternity Hospital Ain Shams University  Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3979-8825","authenticated-orcid":false,"given":"Alaa Sayed","family":"Hassanin","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Faculty of Medicine, Ain Shams Maternity Hospital Ain Shams University  Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sherif Hanafi","family":"Hussain","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Faculty of Medicine, Ain Shams Maternity Hospital Ain Shams University  Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jilan Tarek","family":"Elsayed","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Faculty of Medicine, Ain Shams Maternity Hospital Ain Shams University  Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5701-919X","authenticated-orcid":false,"given":"Maya M.","family":"Abdelrazek","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Faculty of Medicine, Ain Shams Maternity Hospital Ain Shams University  Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,5,27]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm12144828"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/biom14060616"},{"issue":"1","key":"e_1_2_9_4_1","first-page":"33","article-title":"Adenomyosis: diagnosis and management","volume":"105","author":"Schrager S","year":"2022","journal-title":"Am Fam Physician"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmig.2015.11.004"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1017\/9781108582322.046"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics13132182"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0002-9378(11)91551-8"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1447-0756.1998.tb00090.x"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.21608\/mjcu.2019.53351"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016349.2010.512061"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/16.11.2427"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinimag.2021.11.012"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/aogs.14139"}],"container-title":["International Journal of Gynecology &amp; Obstetrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijgo.70253","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,28]],"date-time":"2025-11-28T09:31:01Z","timestamp":1764322261000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1002\/ijgo.70253"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,27]]},"references-count":13,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,11]]}},"alternative-id":["10.1002\/ijgo.70253"],"URL":"https:\/\/doi.org\/10.1002\/ijgo.70253","archive":["Portico"],"relation":{},"ISSN":["0020-7292","1879-3479"],"issn-type":[{"value":"0020-7292","type":"print"},{"value":"1879-3479","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5,27]]},"assertion":[{"value":"2025-01-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-05-17","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-05-27","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}