{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T13:59:26Z","timestamp":1777557566506,"version":"3.51.4"},"reference-count":46,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,6,10]],"date-time":"2025-06-10T00:00:00Z","timestamp":1749513600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","award":["001"],"award-info":[{"award-number":["001"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Gynecology &amp; Obste"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Polycystic ovary syndrome (PCOS) is a prevalent endocrine disorder in women of reproductive age, associated with genetic and environmental factors, including microRNA (miRNA) gene polymorphisms.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To evaluate the association between miRNA gene polymorphisms and PCOS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Search Strategy<\/jats:title>\n                    <jats:p>PubMed, Embase, Web of Science, and Scopus databases were searched to September 2024, using MeSH terms including \u201cMicroRNAs\u201d, \u201cPolymorphism, Single Nucleotide,\u201d and \u201cPolycystic Ovary Syndrome\u201d.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Selection Criteria<\/jats:title>\n                    <jats:p>Case\u2013control studies investigating the relationship between miRNA gene polymorphism and PCOS were included.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Data Collection and Analysis<\/jats:title>\n                    <jats:p>Two researchers collected the data independently. The risk of bias was assessed using the Newcastle\u2010Ottawa Scale (NOS). Data synthesis was performed using RevMan 5.4, and the strength of the evidence was evaluated using the grading of recommendations assessment, development, and evaluation (GRADE) approach.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Main Results<\/jats:title>\n                    <jats:p>Five case\u2013control studies were included in the systematic review, encompassing 985 patients with PCOS and 1004 healthy controls. The meta\u2010analysis included data from 870 PCOS patients and 889 controls. The GG genotype of miR\u2010146a rs2910164 was significantly associated with a protective effect against PCOS, while the GC and CC genotypes were linked to increased PCOS risk. In contrast, the TT genotype of miR\u2010196a\u20102 rs11614913 was associated with heightened PCOS susceptibility. However, the certainty of evidence supporting these associations was low, indicating that the true effects may differ from the observed estimates.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>miRNA polymorphisms, specifically the GG genotype of miR\u2010146a rs2910164 and the GC, CC, and TT genotypes of miR\u2010196a\u20102 rs11614913 seem to be associated with an increased risk of PCOS, warranting further large\u2010scale studies to validate these associations.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ijgo.70255","type":"journal-article","created":{"date-parts":[[2025,6,12]],"date-time":"2025-06-12T11:25:58Z","timestamp":1749727558000},"page":"629-638","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Genetic association between\n                    <scp>microRNA<\/scp>\n                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