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Diffuse peritoneal cysts in this population can be difficult to distinguish from disseminated gynecologic malignancy on imaging and laboratory evaluation and will often be managed by gynecologists and gynecologic oncologists. Preoperative diagnosis may be suspected in the setting of findings of thin\u2010walled cystic lesions on imaging with indicative surgical or clinical history; however, given the risk of malignancy in this population, tissue diagnosis is necessary to exclude more serious diagnoses. Once the diagnosis of peritoneal inclusion cysts has been made, both diagnostic biopsy and complete resection of disease are reasonable treatment strategies, depending on patient goals and symptoms. There is no evidence supporting adjuvant therapy in the treatment or prevention of recurrence of peritoneal inclusion cysts in the post\u2010menopausal population. We present two cases that demonstrate these diagnostic and treatment principles for the gynecologic audience and summarize the existing evidence base for management these lesions.<\/jats:p>","DOI":"10.1002\/ijgo.70263","type":"journal-article","created":{"date-parts":[[2025,6,25]],"date-time":"2025-06-25T10:29:07Z","timestamp":1750847347000},"page":"621-628","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Diffuse peritoneal inclusion cysts masquerading as disseminated gynecologic malignancy in post\u2010menopausal females: Two cases and a review of the literature"],"prefix":"10.1002","volume":"171","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4329-7831","authenticated-orcid":false,"given":"Hadley W.","family":"Reid","sequence":"first","affiliation":[{"name":"Division of Gynecologic Oncology, Department of Obstetrics and Gynecology Massachusetts General Hospital, Harvard Medical School  Boston Massachusetts USA"},{"name":"Division of Gynecologic Oncology, Department of Obstetrics, Gynecology, and Reproductive Biology Brigham and Women's Hospital  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seth A.","family":"Wander","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Medical Oncology Massachusetts General Hospital  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos","family":"Parra\u2010Herran","sequence":"additional","affiliation":[{"name":"Department of Pathology Brigham and Women's Hospital, Harvard Medical School  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Victoria","family":"Wang","sequence":"additional","affiliation":[{"name":"Division of Gynecologic Oncology, Department of Obstetrics, Gynecology, and Reproductive Biology Brigham and Women's Hospital  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valentina","family":"Zanfagnin","sequence":"additional","affiliation":[{"name":"Department of Pathology Massachusetts General Hospital, Harvard Medical School  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander","family":"Melamed","sequence":"additional","affiliation":[{"name":"Division of Gynecologic Oncology, Department of Obstetrics and Gynecology Massachusetts General Hospital, Harvard Medical School  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jessica","family":"St Laurent","sequence":"additional","affiliation":[{"name":"Division of Gynecologic Oncology, Department of Obstetrics, Gynecology, and Reproductive Biology Brigham and Women's Hospital  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Varvara","family":"Mazina","sequence":"additional","affiliation":[{"name":"Division of Gynecologic Oncology, Department of Obstetrics and Gynecology Massachusetts General Hospital, Harvard Medical School  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,6,25]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197908)44:2<692::aid-cncr2820440242>3.0.co;2-6"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000002249"},{"volume-title":"Organisation mondiale de la sant\u00e9, Centre international de recherche sur le cancer, editors. 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