{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,22]],"date-time":"2025-11-22T15:31:06Z","timestamp":1763825466517,"version":"3.45.0"},"reference-count":50,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,6,10]],"date-time":"2025-06-10T00:00:00Z","timestamp":1749513600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100017686","name":"Fujian Provincial Health Technology Project","doi-asserted-by":"publisher","award":["2024GGA032"],"award-info":[{"award-number":["2024GGA032"]}],"id":[{"id":"10.13039\/501100017686","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Gynecology &amp;amp; Obste"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Although clinical observational studies have reported a connection between preeclampsia (PE) and thyroid disease, the underlying causality remains unclear. The study aims to assess the potential causality between PE and thyroid disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>A two\u2010sample bidirectional Mendelian randomization (MR) study was conducted using the summary statistics from the genome\u2010wide association studies on PE (128\u2009668 individuals), thyroid cancer (407\u2009746 individuals), hypothyroidism (410\u2009141 individuals), hyperthyroidism (460\u2009499 individuals), Graves' disease (458\u2009620 individuals), and Hashimoto thyroiditis (395\u2009640 individuals). The inverse variance weighted approach was used as the main method. Additionally, we performed multiple method analyses, including MR\u2010Egger, simple mode, weighted median, and weighted mode tests to extensively examine our results. Furthermore, we conducted sensitivity analyses such as the leave\u2010one\u2010out test, Cochran's Q test, and the MR\u2010Egger intercept test to evaluate the reliability and stability of our findings.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The MR analysis revealed that genetic susceptibility to hypothyroidism, hyperthyroidism, Graves' disease and Hashimoto thyroiditis was significantly associated with PE. The odds ratios (ORs) for them were as follows: hypothyroidism: OR 1.06 (95% confidence interval [CI], 1.00\u20131.12;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.031); hyperthyroidism: OR 1.06 (95% CI, 1.00\u20131.13;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.049), Graves' disease: OR 1.06 (95% CI, 1.01\u20131.10;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.008); Hashimoto thyroiditis: OR 1.10 (95% CI, 1.03\u20131.17;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.003). However, there was no statistically significant association between thyroid cancer and PE (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&gt;\u20090.05). A reverse MR analysis indicated that genetically predicted PE was not statistically significantly associated with these five thyroid diseases (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&gt;\u20090.05). Our sensitivity analyses demonstrated the absence of significant horizontal pleiotropy, ensuring the stability and reliability of our findings.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our study suggests a causality between hypothyroidism, hyperthyroidism, Graves' disease, Hashimoto thyroiditis and PE. However, no statistically significant association was found between thyroid cancer and PE. Conversely, PE did not show a causal effect on any of these five thyroid diseases.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ijgo.70298","type":"journal-article","created":{"date-parts":[[2025,6,12]],"date-time":"2025-06-12T11:25:58Z","timestamp":1749727558000},"page":"1231-1245","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Thyroid disorders as potential causal factors for preeclampsia: A two\u2010sample bidirectional mendelian randomization study"],"prefix":"10.1002","volume":"171","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8714-9590","authenticated-orcid":false,"given":"Feng","family":"Zhan","sequence":"first","affiliation":[{"name":"College of Engineering Fujian Jiangxia University  Fuzhou China"},{"name":"School of Electronic Information Engineering Taiyuan University of Science and Technology  Taiyuan Shanxi 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