{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T03:52:17Z","timestamp":1784173937381,"version":"3.55.0"},"reference-count":29,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,6,26]],"date-time":"2025-06-26T00:00:00Z","timestamp":1750896000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,6,26]],"date-time":"2025-06-26T00:00:00Z","timestamp":1750896000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Gynecology &amp;amp; Obste"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Meconium\u2010stained amniotic fluid (MSAF) is uncommon in preterm deliveries and raises concerns about maternal and neonatal infectious risks. We aimed to evaluate maternal, perinatal, and microbiological outcomes in preterm deliveries complicated by MSAF compared to clear amniotic fluid (AF) and to assess outcomes in preterm versus term deliveries with MSAF.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective cohort study included singleton pregnancies delivered at 24\u201342\u2009weeks at a tertiary hospital (March 2020\u2013May 2024), with documented AF color. Chorioamniotic swab culture results were analyzed, and clinical outcomes compared using univariate and multivariate analyses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Of 1550 preterm deliveries, 93 (6%) were complicated by MSAF. For preterm births with MSAF compared to AF, the rates were higher of clinical chorioamnionitis, puerperal endometritis, maternal bacteremia, and adverse neonatal outcomes, including respiratory distress syndrome and the need for ventilation (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001 for all). Positive chorioamniotic swab cultures were more frequent in preterm MSAF than preterm clear AF (26 [28.0%] vs. 168 [11.5%],\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001), with higher isolation of Enterobacteriaceae (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.030) and group B streptococcus (GBS;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.040). Comparing preterm versus term deliveries, among those complicated by MSAF, the rates were higher of clinical chorioamnionitis, endometritis, maternal bacteremia, early\u2010onset sepsis, and positive chorioamniotic cultures (26 [28.0%] vs. 220 [10.0%],\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001), particularly Enterobacteriaceae (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.001) and\n                      <jats:italic>Enterococcus<\/jats:italic>\n                      spp. (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.003).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Preterm deliveries with MSAF, compared to preterm clear AF and term MSAF, were associated with increased maternal infections, neonatal morbidity, and distinct microbial colonization. Chorioamniotic swab cultures might aid in identifying high\u2010risk preterm births requiring targeted infection management.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ijgo.70337","type":"journal-article","created":{"date-parts":[[2025,6,26]],"date-time":"2025-06-26T07:08:34Z","timestamp":1750921714000},"page":"420-427","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Preterm meconium\u2010stained amniotic fluid: A red flag for infection and adverse perinatal outcomes"],"prefix":"10.1002","volume":"172","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0131-3936","authenticated-orcid":false,"given":"Raneen","family":"Abu Shqara","sequence":"first","affiliation":[{"name":"Raya Strauss Wing of Obstetrics and Gynecology Galilee Medical Center  Nahariya Israel"},{"name":"Azrieli Faculty of Medicine Bar Ilan University  Safed Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neta","family":"Hoffman","sequence":"additional","affiliation":[{"name":"Raya Strauss Wing of Obstetrics and Gynecology Galilee Medical Center  Nahariya Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lior","family":"Lowenstein","sequence":"additional","affiliation":[{"name":"Raya Strauss Wing of Obstetrics and Gynecology Galilee Medical Center  Nahariya Israel"},{"name":"Azrieli Faculty of Medicine Bar Ilan University  Safed Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maya","family":"Frank Wolf","sequence":"additional","affiliation":[{"name":"Raya Strauss Wing of Obstetrics and Gynecology Galilee Medical Center  Nahariya Israel"},{"name":"Azrieli Faculty of Medicine Bar Ilan University  Safed Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,6,26]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.OGRM.2016.05.001"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.3389\/FPED.2023.1110891"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/children10020215"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.3109\/14767058.2013.844124"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(91)90529-Z"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2022.11.1283"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/CHILDREN11060673"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/CHILDREN10050780"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1177\/0883073810382907"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/JP.2008.154"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2008.150425"},{"key":"e_1_2_11_13_1","first-page":"115","article-title":"Meconium\u2010stained amniotic fluid: increased risk for adverse neonatal outcome","volume":"84","author":"Berkus MD","year":"1994","journal-title":"Obstet Gynecol"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1080\/14767058.2016.1236246"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/aog.0000000000002236"},{"key":"e_1_2_11_16_1","volume-title":"WHO Recommendations for Prevention and Treatment of Maternal Peripartum Infections Executive Summary","author":"World Health Organization","year":"2015"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2020.09.044"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eclinm.2019.11.020"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2020.12.052"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/0029-7844(95)00265-S"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/SJ.JP.7210774"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0301-2115(98)00141-9"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/S12098-012-0914-6"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/321545"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2002.021949"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0029-7844(97)00308-6"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0B013E3182117A26"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.SINY.2011.09.001"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/aogs.13689"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.4103\/JCN.JCN_21_23"}],"container-title":["International Journal of Gynecology &amp; 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