{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:45:43Z","timestamp":1786977943983,"version":"build-2736575974"},"reference-count":19,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,7,4]],"date-time":"2025-07-04T00:00:00Z","timestamp":1751587200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,7,4]],"date-time":"2025-07-04T00:00:00Z","timestamp":1751587200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Gynecology &amp;amp; Obste"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To explore the incidence of congenital bleeding disorders (CBD), which may result in anemia, in a large cohort of women referred for heavy menstrual bleeding (HMB) in a specialized gynecologic unit.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Between January 2022 and January 2024, all women referred for HMB were screened. All benefited from Higham and ISTH\u2010BAT scoring to assess the importance of blood loss. Gynecologic ultrasound was performed and antecedents were recorded. Standard coagulation tests, complete blood count, hemoglobin, ferritin, and C\u2010reactive protein assays were performed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among 454 women, medical history disclosed eight cases of CBD (six von Willebrand diseases, one case of FVII deficiency and a CBD carrier). In the 446 others, coagulation tests identified 41 (9.2%) with von Willebrand Factor deficiency (VWF:GPAbR \u2264\u200950\u2009IU\/dL), very severe in three cases (0.7%). Overt anemia (hemoglobin \u2264120\u2009g\/L) was found in 155 (34.7%) women, and low ferritin (&lt;15\u2009\u03bcg\/L) in 191 (42.8%), with less than 30\u2009\u03bcg\/L for 324 patients (72.5%). Although the incidence of transfusions was limited, 341 (75.1%) of these women had received oral iron supplementation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Laboratory screening in a large series of women with HMB disclosed potential CBD in almost 10% of them and overt or rampant anemia in at least 40%. These observations support the need to reinforce the detection and management of HMB.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ijgo.70352","type":"journal-article","created":{"date-parts":[[2025,7,4]],"date-time":"2025-07-04T08:25:22Z","timestamp":1751617522000},"page":"250-254","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Evaluation of coagulation disorders and iron deficiency in women with heavy menstrual bleeding"],"prefix":"10.1002","volume":"172","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3103-1737","authenticated-orcid":false,"given":"Lucia","family":"Rugeri","sequence":"first","affiliation":[{"name":"Service d'H\u00e9matologie Biologique et d'H\u00e9mostase Clinique Hospices Civils de Lyon  Lyon France"},{"name":"Service de Gyn\u00e9cologie\u2010Obst\u00e9trique, H\u00f4pital de la Croix Rousse Hospices Civils de Lyon  Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yelena","family":"Fruchou","sequence":"additional","affiliation":[{"name":"Service de Gyn\u00e9cologie\u2010Obst\u00e9trique, H\u00f4pital de la Croix Rousse Hospices Civils de Lyon  Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline","family":"Brodbeck","sequence":"additional","affiliation":[{"name":"Service de Gyn\u00e9cologie\u2010Obst\u00e9trique, H\u00f4pital de la Croix Rousse Hospices Civils de Lyon  Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marianne","family":"Bastien","sequence":"additional","affiliation":[{"name":"Service de Gyn\u00e9cologie\u2010Obst\u00e9trique, H\u00f4pital de la Croix Rousse Hospices Civils de Lyon  Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amandine","family":"Lioux","sequence":"additional","affiliation":[{"name":"Service de Gyn\u00e9cologie\u2010Obst\u00e9trique, H\u00f4pital de 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