{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T23:57:58Z","timestamp":1788998278556,"version":"build-2803163510"},"reference-count":8,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,7,7]],"date-time":"2025-07-07T00:00:00Z","timestamp":1751846400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,7,7]],"date-time":"2025-07-07T00:00:00Z","timestamp":1751846400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Gynecology &amp;amp; Obste"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Craniopharyngiomas are the most common non\u2010neuroepithelial intracerebral neoplasms in children but rarely occur before birth, and are typically associated with a poor prognosis. We present the case of a 39\u2010year\u2010old woman with a spontaneously conceived singleton pregnancy. At 20 weeks of gestation, ultrasound detected a 44\u00d725 mm heterogeneously hyperechogenic intracranial mass located at the base of the sphenoid bone, extending bilaterally. Due to the poor prognosis, legal pregnancy termination was performed, followed by fetal autopsy. The 20\u2010week\u2010old male fetus weighed 528g. External examination revealed only macrocephaly. Internal evaluation identified a yellowish, heterogeneous suprasellar mass. Histological analysis showed squamous epithelium with peripheral palisading, stellate reticulum, wet keratin, and calcifications\u2014features consistent with adamantinomatous craniopharyngioma. Tumor cells were immunoreactive for high\u2010 and low\u2010 to intermediate molecular weight cytokeratins and SOX9, while no pituitary hormones or neuroendocrine markers were expressed. Next\u2010generation sequencing of tumor tissue revealed a pathogenic somatic CTNNB1 mutation (c.121A&gt;G, p.Thr41Ala), with no BRAF p.Val600Glu mutation and no germline variants detected. No extracranial abnormalities were observed. This case supports the inclusion of adamantinomatous craniopharyngioma in the differential diagnosis of congenital sellar and suprasellar masses despite its rarity. The identification of a somatic CTNNB1 mutation aligns with findings in postnatally diagnosed cases. Thorough histopathologic and molecular characterization is essential to guide prenatal counseling and improve management of affected fetuses and newborns.<\/jats:p>","DOI":"10.1002\/ijgo.70357","type":"journal-article","created":{"date-parts":[[2025,7,7]],"date-time":"2025-07-07T08:18:13Z","timestamp":1751876293000},"page":"645-649","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Intrauterine\u2010diagnosed fetal intracranial adamantinomatous craniopharyngioma: A case report with histopathological and molecular characterization"],"prefix":"10.1002","volume":"172","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7113-045X","authenticated-orcid":false,"given":"Eva Manuela","family":"Pena\u2010Burgos","sequence":"first","affiliation":[{"name":"Pathology Department Gregorio Mara\u00f1\u00f3n General University Hospital  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina","family":"Arias Duart","sequence":"additional","affiliation":[{"name":"Pathology Department Gregorio Mara\u00f1\u00f3n General University Hospital  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco","family":"Arias Lotto","sequence":"additional","affiliation":[{"name":"Pathology Department Gregorio Mara\u00f1\u00f3n General University Hospital  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Coral","family":"Bravo\u2010Arribas","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynecology Department Gregorio Mara\u00f1\u00f3n General University Hospital  Madrid Spain"},{"name":"Department of Public and Maternal and Child Health, School of Medicine Complutense University of Madrid  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Mart\u00ednez\u2010Payo","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynecology Department Gregorio Mara\u00f1\u00f3n General University Hospital  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Antonio","family":"De Le\u00f3n\u2010Luis","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynecology Department Gregorio Mara\u00f1\u00f3n General University Hospital  Madrid Spain"},{"name":"Department of Public and Maternal and Child Health, School of Medicine Complutense University of Madrid  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Su\u00e1rez\u2010Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"Genomics Unit Gregorio Mara\u00f1\u00f3n General University Hospital  Madrid Spain"},{"name":"Genomics Unit Gregorio Mara\u00f1\u00f3n Health Research Institute  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose Juan","family":"Pozo\u2010Kreilinger","sequence":"additional","affiliation":[{"name":"Pathology Department La Paz University Hospital  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rita Mar\u00eda","family":"Regojo\u2010Zapata","sequence":"additional","affiliation":[{"name":"Pathology Department La Paz University Hospital  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,7,7]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0029-1214245"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11102-015-0682-1"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00381-016-3249-1"},{"key":"e_1_2_8_5_1","volume-title":"Placental and Gestational Pathology Hardback with Online Resource (Diagnostic Pediatric Pathology)","author":"Redline RW","year":"2018"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.2350\/14-06-1506-CR.1"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00247-020-04777-z"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2011-2187"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-014-1270-6"}],"container-title":["International Journal of Gynecology &amp; 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