{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T08:14:21Z","timestamp":1771316061689,"version":"3.50.1"},"reference-count":37,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,7,17]],"date-time":"2025-07-17T00:00:00Z","timestamp":1752710400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,7,17]],"date-time":"2025-07-17T00:00:00Z","timestamp":1752710400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001336","name":"University of the Witwatersrand, Johannesburg","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001336","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001321","name":"National Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001321","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010753","name":"National Health Laboratory Service","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010753","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Gynecology &amp;amp; Obste"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Universal screening for gestational diabetes mellitus (GDM) using the oral glucose tolerance test (OGTT) has been recommended. In resource\u2010poor environments, OGTTs are only administered to high\u2010risk cases. In countries such as South Africa, where female obesity is common, this translates into high numbers of tests. We therefore investigated glycated hemoglobin (HbA1c), glycated albumin (GA) and fasting plasma glucose (FPG) as OGTT alternatives.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This was a cross\u2010sectional study in black South African women between 24 and 32\u2009weeks of gestation who were at high risk for GDM (\n                      <jats:italic>N<\/jats:italic>\n                      \u2009=\u2009477). All women underwent an OGTT and were classified as non\u2010GDM or GDM based on the International Association of Diabetes and Pregnancy Study Group (IADPSG) criteria. Demographic and anthropometric data were documented, and blood glucose, GA and HbA1c levels were measured using standardized laboratory procedures. Cut\u2010points for GDM diagnosis using HbA1c and GA were calculated using receiver operating characteristic (ROC) curve analysis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The sensitivity and specificity of HbA1c at a 5.5% cut\u2010point for GDM diagnosis were 54% and 80% and for GA at a 37.56% cut\u2010point were 54% and 83% whilst FPG at a 5.1\u2009mmol\/L (92\u2009mg\/dL) cut\u2010point were 87% and 100%, respectively, missing 10 of 78 GDM cases. Applying an FPG cut\u2010point of 4.6\u2009mmol\/L (83\u2009mg\/dL), nine of the 10 remaining GDM cases were identified, with sensitivity and specificity of 90% and 75%, respectively. This two\u2010tiered approach missed one of 78 GDM cases.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>FPG is a viable method for GDM diagnosis that when used in a two\u2010tiered modality reduces the number of required OGTTs by 77%.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ijgo.70370","type":"journal-article","created":{"date-parts":[[2025,7,17]],"date-time":"2025-07-17T12:09:16Z","timestamp":1752754156000},"page":"549-557","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Fasting plasma glucose performs better than glycated hemoglobin and glycated albumin for diagnosing gestational diabetes"],"prefix":"10.1002","volume":"172","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5715-7146","authenticated-orcid":false,"given":"Lungile","family":"Khambule","sequence":"first","affiliation":[{"name":"Department of Chemical Pathology University of Witwatersrand  Johannesburg South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lawrence","family":"Chauke","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, School of Clinical Medicine, Faculty of Health Sciences University of the Witwatersrand &amp; Charlotte Maxeke Johannesburg Academic Hospital  Johannesburg South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nigel J.","family":"Crowther","sequence":"additional","affiliation":[{"name":"Department of Chemical Pathology University of Witwatersrand  Johannesburg South Africa"},{"name":"Department of Chemical Pathology National Health Laboratory Service  Johannesburg South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaya A.","family":"George","sequence":"additional","affiliation":[{"name":"National Health Laboratory Service, South Africa, Department of Chemical Pathology University of Witwatersrand and Wits Diagnostic Innovation Hub, Wits Health Consortium  Johannesburg South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,7,17]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc21-S002"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/tmi.12521"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.7196\/SAMJ.2017.v107i6.12043"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2018.03.012"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0707943"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc09-1848"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-5491.1992.tb01900.x"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.4038\/cmj.v57i1.4193"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0175288"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.7196\/SAMJ.2019.v110i1.14089"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2015.2808"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.4239\/wjd.v6.i8.1045"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.4093\/dmj.2012.36.2.98"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ekir.2017.11.009"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.3747\/pdi.2008.00243"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1080\/14767058.2017.1333103"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc09-9033"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.27.2007.S88"},{"key":"e_1_2_10_20_1","unstructured":"Recommendations Diabetes in pregnancy: management from preconception to the postnatal period Guidance NICE 2015. 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