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However, there is little evidence for the need of giving IgG anti\u2010D prophylaxis to RhD\u2010negative women in first\u2010trimester abortions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To analyze the international and national evidence\u2010based guidelines on Rh testing and anti\u2010D prophylaxis in first\u2010trimester abortion, along with current literature both supporting and opposing this practice, to facilitate informed decision making in clinical practice.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Search Strategy<\/jats:title>\n                    <jats:p>A systematic search was conducted in Pubmed\/MEDLINE, EMBASE, Cochrane Library, Google Scholar, and Gry literature for publications from January 1, 2003 to January 17, 2024.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Selection Criteria<\/jats:title>\n                    <jats:p>Guidelines, reviews, meta\u2010analyses, observational and qualitative studies, randomized trials, real\u2010world data, and cohort studies that addressed the use of IgG anti\u2010D prophylaxis in first\u2010trimester abortions were included.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Data Collection and Analysis<\/jats:title>\n                    <jats:p>Identified studies were screened and assessed independently by two authors. A standardized extraction grid was used to extract information from the selected articles.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Main Results<\/jats:title>\n                    <jats:p>Guidelines published from 2022 onwards, such as those from the World Health Organization, recommend against anti\u2010D for women undergoing first\u2010trimester abortion. In contrast, most older guidelines recommend RhD testing and the administration of IgG anti\u2010D prophylaxis in abortions even before 12\u2009weeks of amenorrhea, although exact gestational age thresholds vary widely. These discrepancies in the management of RhD\u2010negative women undergoing first\u2010trimester abortion are caused by different interpretations of the available evidence, IgG anti\u2010D availability, cultural and social influences, as well as legal and regulatory considerations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This review highlights the need for evidence\u2010based, harmonized guidelines on IgG anti\u2010D prophylaxis in first\u2010trimester abortions. It is crucial for healthcare providers to stay informed on the latest recommendations and engage in shared decision\u2010making with women undergoing first\u2010trimester abortion.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ijgo.70404","type":"journal-article","created":{"date-parts":[[2025,7,29]],"date-time":"2025-07-29T12:24:19Z","timestamp":1753791859000},"page":"759-771","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Rhesus testing and anti\u2010D prophylaxis in RhD\u2010negative women undergoing first\u2010trimester abortion\u2014Systematic Review and Opinion"],"prefix":"10.1002","volume":"172","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6516-1444","authenticated-orcid":false,"given":"Kristina","family":"Gemzell\u2010Danielsson","sequence":"first","affiliation":[{"name":"Division of Obstetrics and Gynecology, Department of Women's and Children's Health Karolinska Institutet  Stockholm 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