{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T05:52:38Z","timestamp":1791179558639,"version":"4.1.0"},"reference-count":21,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,7,29]],"date-time":"2025-07-29T00:00:00Z","timestamp":1753747200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,7,29]],"date-time":"2025-07-29T00:00:00Z","timestamp":1753747200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Gynecology &amp; Obste"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To evaluate the potential of an artificial intelligence (AI)\u2010driven large language model, ChatGPT 4.0, to provide personalized, evidence\u2010based treatment recommendations for uterine fibroids.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>ChatGPT 4.0 was trained using evidence\u2010based data from Uptodate and German medical literature. The algorithm generated individualized recommendations based on clinical characteristics and patient preferences. Usability and quality were assessed through questionnaires completed by 40 gynecologists and 45 women with fibroids.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Most gynecologists found the algorithm user\u2010friendly and comprehensive, with 15 expressing a willingness to integrate it into practice and 24 acknowledging its potential to enhance healthcare efficiency. Although only half believed it would improve patient outcomes, the tool was generally well received. Patients found the algorithm easy to understand and helpful for exploring treatment options, with the majority feeling it empowered informed discussions with their healthcare providers. A minority expressed dissatisfaction with usability or helpfulness.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>ChatGPT 4.0 offers a promising AI\u2010driven tool for personalized fibroid management in the absence of formal guidelines. Although not a substitute for official recommendations, it could support clinical decision making and enhance patient education. Further integration with standardized guidelines and prospective trials is needed to optimize its clinical utility.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ijgo.70407","type":"journal-article","created":{"date-parts":[[2025,7,29]],"date-time":"2025-07-29T11:39:55Z","timestamp":1753789195000},"page":"1104-1113","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Leveraging artificial intelligence for evidence\u2010based recommendations in uterine fibroid therapy: Addressing the unmet need in German healthcare\u2014A clinical trial"],"prefix":"10.1002","volume":"172","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8516-6242","authenticated-orcid":false,"given":"Iason","family":"Psilopatis","sequence":"first","affiliation":[{"name":"Department of Gynecology and Obstetrics Universit\u00e4tsspital Basel  Basel Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Lotz","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics Universit\u00e4tsklinikum Erlangen, Comprehensive Cancer Center Erlangen\u2010EMN (CCC ER\u2010EMN), Friedrich\u2010Alexander\u2010Universit\u00e4t Erlangen\u2010N\u00fcrnberg (FAU)  Erlangen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadezda","family":"Sipulina","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics Universit\u00e4tsklinikum Erlangen, Comprehensive Cancer Center Erlangen\u2010EMN (CCC ER\u2010EMN), Friedrich\u2010Alexander\u2010Universit\u00e4t Erlangen\u2010N\u00fcrnberg (FAU)  Erlangen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felix","family":"Heindl","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics Universit\u00e4tsklinikum Erlangen, Comprehensive Cancer Center Erlangen\u2010EMN (CCC ER\u2010EMN), Friedrich\u2010Alexander\u2010Universit\u00e4t Erlangen\u2010N\u00fcrnberg (FAU)  Erlangen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georgia","family":"Levidou","sequence":"additional","affiliation":[{"name":"Department of Pathology, Nuremberg Clinic Paracelsus Medical University  Nuremberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julius","family":"Emons","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics Universit\u00e4tsklinikum Erlangen, Comprehensive Cancer Center Erlangen\u2010EMN (CCC ER\u2010EMN), Friedrich\u2010Alexander\u2010Universit\u00e4t Erlangen\u2010N\u00fcrnberg (FAU)  Erlangen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,7,29]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1209993"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijgo.13102"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.2147\/IJWH.S138982"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/1472-6874-12-6"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0043-106257"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0043-106259"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13244-022-01244-1"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2023.06.021"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1055\/a-2077-1387"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.3389\/frai.2023.1169595"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00404-024-07667-z"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.21873\/invivo.13614"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/1471-0528.17929"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.3238\/arztebl.m2024.0081"},{"key":"e_1_2_9_16_1","volume-title":"UpToDate","author":"Stewart EA","year":"2024"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.3238\/arztebl.2016.0242"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.3238\/arztebl.2014.0877"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.3233\/THC-231482"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.2196\/54737"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2589-7500(23)00245-5"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOU.0000000000000692"}],"container-title":["International Journal of Gynecology &amp; 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