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The GRADE and QUADAS\u20102 tool was used for quality evaluation. The pooled sensitivity and specificity for CIN2+ and CIN3+ were estimated using random effects models, with results and heterogeneity assessments presented in forest plots. Pretest\u2010posttest probability (PPP) plots were constructed to evaluate the detection rates of CIN3+ in ASC\u2010US and LSIL patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Main Results<\/jats:title>\n                    <jats:p>Twenty\u2010one studies with 6394 participants were included. The pooled specificity of p16\/Ki\u201067 dual\u2010staining was higher than that of HPV tests (CIN2+: 0.73 [95% confidence interval [CI] 0.65\u20130.80] versus 0.41 [95% CI 0.33\u20130.50]; CIN3+: 0.61 [95% CI 0.53\u20130.69] versus 0.33 [95% CI 0.23\u20130.45]). Summary receiver operating characteristic curve analysis demonstrated p16\/Ki\u201067 dual\u2010staining had better diagnostic accuracy for CIN2+ than HPV tests (area under the curve: 0.88 [95% CI 0.85\u20130.90] versus 0.79 [95% CI 0.75\u20130.82]). Pretest\u2010posttest probability (PPP) plots highlighted the superior performance of p16\/Ki\u201067 dual\u2010staining for colposcopy referrals in LSIL patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>P16\/Ki\u201067 dual\u2010staining offers greater specificity for detecting CIN2+\/CIN3+ in ASC\u2010US and LSIL triage, particularly for LSIL. It holds potential as an alternative to HPV tests in resource\u2010limited settings or LSIL cases, warranting further research to refine its application in diverse populations.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ijgo.70432","type":"journal-article","created":{"date-parts":[[2025,8,11]],"date-time":"2025-08-11T11:56:01Z","timestamp":1754913361000},"page":"815-827","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Application of\n                    <scp>P16<\/scp>\n                    \/Ki\u201067 dual\u2010staining for the detection of high\u2010grade cervical lesions in the triage of patients with minor abnormal cytology: A meta\u2010analysis"],"prefix":"10.1002","volume":"172","author":[{"given":"Hua","family":"Zhang","sequence":"first","affiliation":[{"name":"The State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, School of Public Health Xiamen University  Xiamen Fujian China"},{"name":"Department of Cancer Epidemiology, National Cancer Center\/National Clinical Research Center for Cancer\/ Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Dai","sequence":"additional","affiliation":[{"name":"Department of Cancer Epidemiology, National Cancer Center\/National Clinical Research Center for Cancer\/ Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hang","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Cancer Epidemiology, National Cancer Center\/National Clinical Research Center for Cancer\/ Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Yang","sequence":"additional","affiliation":[{"name":"The State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, School of Public Health Xiamen University  Xiamen Fujian China"},{"name":"Department of Cancer Epidemiology, National Cancer Center\/National Clinical Research Center for Cancer\/ Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruoji","family":"Pi","sequence":"additional","affiliation":[{"name":"Department of Cancer Epidemiology, National Cancer Center\/National Clinical Research Center for Cancer\/ Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tingyuan","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Cancer Epidemiology, National Cancer Center\/National Clinical Research Center for Cancer\/ Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing China"},{"name":"Department of Experimental Research, Sichuan Clinical Research Center for Cancer, Sichuan Cancer Hospital &amp; 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