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We also searched gray literature and hand\u2010searched the list of relevant references.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Selection Criteria<\/jats:title>\n                    <jats:p>We included all original studies in the English language that reported prevalence data on discontinuation and its follow\u2010up pregnancy\/live birth rate.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Data Collection and Analysis<\/jats:title>\n                    <jats:p>Two independent reviewers performed study quality assessment, data extraction and analysis. A random\u2010effects model was used to pool the overall prevalence estimates and 95% confidence intervals (95% CI).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Main Results<\/jats:title>\n                    <jats:p>A total of 62 studies involving 330\u2009593 infertile patients from 20 countries were included in the review. The overall pooled prevalence of discontinuation across all fertility treatments was 0.36 (95% CI: 0.31\u20130.41). Specifically, the prevalence of discontinuation in assisted reproductive treatments was 0.37 (95% CI: 0.32\u20130.42). Prevalence rates of discontinuation show an increasing trend with the course of treatment, particularly within the first four treatment cycles, ranging from 23% after the first failed cycle to 36% after the fourth failed cycle. Among these discontinuers, the follow\u2010up pregnancy rates were 0.22 (95% CI: 0.12\u20130.32), and the live birth rates were 0.21 (95% CI: 0.15\u20130.27).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This review provides evidence that treatment discontinuation occurs in approximately one in every three infertile patients. Further research is warranted to develop effective intervention strategies for preventing and managing early treatment discontinuation in this population.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ijgo.70440","type":"journal-article","created":{"date-parts":[[2025,8,7]],"date-time":"2025-08-07T08:54:11Z","timestamp":1754556851000},"page":"772-785","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Worldwide prevalence of discontinuation in fertility treatment: A systematic review and meta\u2010analysis"],"prefix":"10.1002","volume":"172","author":[{"given":"Quan","family":"Shen","sequence":"first","affiliation":[{"name":"Xiangya School of Nursing Central South University  Changsha Hunan China"},{"name":"Department of Obstetrics and Gynecology The Third Xiangya Hospital of Central South University  Changsha Hunan China"},{"name":"Department of Reproductive Medicine The Third XiangYa Hospital of Central South University  Changsha Hunan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tan","family":"He","sequence":"additional","affiliation":[{"name":"Xiangya School of Nursing Central South University  Changsha Hunan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Binglu","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology The Third Xiangya Hospital of Central South University  Changsha Hunan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia","family":"Qu","sequence":"additional","affiliation":[{"name":"Department of Reproductive Medicine The Third XiangYa Hospital of Central South University  Changsha Hunan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ENuo","family":"Peng","sequence":"additional","affiliation":[{"name":"Department of Reproductive Medicine The Third XiangYa Hospital of Central South University  Changsha Hunan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0430-4672","authenticated-orcid":false,"given":"Jun","family":"Lei","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology The Third Xiangya Hospital of Central South University  Changsha Hunan China"},{"name":"Department of Reproductive Medicine The Third XiangYa Hospital of Central South University  Changsha Hunan China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,8,7]]},"reference":[{"key":"e_1_2_10_2_1","unstructured":"World Health Organization.Infertility.2023. 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