{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T05:52:10Z","timestamp":1791179530400,"version":"4.1.0"},"reference-count":25,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,8,11]],"date-time":"2025-08-11T00:00:00Z","timestamp":1754870400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,8,11]],"date-time":"2025-08-11T00:00:00Z","timestamp":1754870400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Gynecology &amp; Obste"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Although liver transplantation has afforded patients with cirrhosis a chance at both survival and motherhood, recipients are at higher risk of pregnancy complications and graft rejection. We aimed to describe our experiences with post\u2010liver transplantation pregnancies over 17\u2009years in Iran.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective observational study included female liver transplant recipients from 2002 to 2019 who became pregnant after their transplantation. Patient characteristics and both maternal and neonatal outcomes and complications, including gestational diabetes mellitus (GDM), pre\u2010eclampsia, premature preterm rupture of membrane (PPROM), live birth, gestational age, birth weight, and mode of delivery were gathered. Graft rejection was evaluated through histopathologic assessment of core needle biopsy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 59 pregnancies were recorded from 39 patients (age at transplantation: 24.79\u2009\u00b1\u20095.61\u2009years, age at conception: 29.67\u2009\u00b1\u20095.82\u2009years), all of which were singleton pregnancies. The most common indication for transplantation was autoimmune hepatitis. Of the 59 pregnancies, 30 (76.9%) resulted in live births, and 36 patients (92.3%) achieved live births overall. PPROM, GDM, and pre\u2010eclampsia occurred in 13%, 7%, and 3% of pregnancies, respectively, while graft rejection was observed in 8% of pregnancies. Six (13%) infants classified as very low birth weight, 18 (39%) as low birth weight, and two (4%) as overweight.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our findings underscore the feasibility of pregnancy following liver transplantation. However, they also emphasize the critical importance of ongoing surveillance and coordinated multidisciplinary collaboration to ensure optimal care for this unique patient population.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ijgo.70453","type":"journal-article","created":{"date-parts":[[2025,8,11]],"date-time":"2025-08-11T12:52:42Z","timestamp":1754916762000},"page":"984-990","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Post\u2010liver transplantation pregnancy outcomes and complications: A 17\u2010year observational study from Iran"],"prefix":"10.1002","volume":"172","author":[{"given":"Alireza","family":"Shamsaeefar","sequence":"first","affiliation":[{"name":"Shiraz Transplant Center, Abu Ali Sina Hospital Shiraz University of Medical Sciences  Shiraz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5019-5641","authenticated-orcid":false,"given":"Mohammad","family":"Eslamian","sequence":"additional","affiliation":[{"name":"Department of Surgery, School of Medicine Isfahan University of Medical Sciences  Isfahan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0928-361X","authenticated-orcid":false,"given":"Mehran","family":"Rashidi","sequence":"additional","affiliation":[{"name":"Department of Surgery, School of Medicine Isfahan University of Medical Sciences  Isfahan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kourosh","family":"Kazemi","sequence":"additional","affiliation":[{"name":"Shiraz Transplant Center, Abu Ali Sina Hospital Shiraz University of Medical Sciences  Shiraz 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