{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T12:03:52Z","timestamp":1781784232075,"version":"3.54.5"},"reference-count":21,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,8,12]],"date-time":"2025-08-12T00:00:00Z","timestamp":1754956800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,8,12]],"date-time":"2025-08-12T00:00:00Z","timestamp":1754956800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Gynecology &amp; Obste"],"published-print":{"date-parts":[[2025,10]]},"abstract":"Abstract<\/jats:title>\n \n Objective<\/jats:title>\n To evaluate the diagnostic and prognostic significance of maternal serum thrombospondin\u20104 (TSP\u20104) levels in pre\u2010eclampsia (PE), including comparisons between early\u2010 and late\u2010onset disease and between mild and severe cases, and to examine associations with adverse perinatal outcomes.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n A prospective study was conducted including 45 pregnant women with PE (stratified by onset type and severity) and 45 gestational age\u2010matched normotensive controls. Serum TSP\u20104 concentrations were measured by enzyme\u2010linked immunosorbent assay (ELISA). Group differences were analyzed, and receiver operating characteristic (ROC) curves were generated to assess the diagnostic performance of TSP\u20104 for PE and its prognostic value for adverse outcomes.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Maternal TSP\u20104 levels were significantly elevated in PE patients compared to controls. Using a cutoff value of >6.42\u2009ng\/mL, TSP\u20104 levels could distinguish PE cases with a sensitivity of 86%, a specificity of 73%, and an area under the curve (AUC) of 0.891 (\n P<\/jats:italic>\n \u2009=\u20090.001). At a cutoff of >7.22\u2009ng\/mL, it was significantly associated with composite adverse neonatal outcomes, with a sensitivity of 76%, a specificity of 74%, and an AUC of 0.742 (\n P<\/jats:italic>\n \u2009=\u20090.001). At a cutoff of >9.72\u2009ng\/mL, it was significantly associated with severe PE, with a sensitivity of 70%, a specificity of 74%, and an AUC of 0.792 (\n P<\/jats:italic>\n \u2009=\u20090.001).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n Maternal serum TSP\u20104 is a promising biomarker in PE, reflecting disease presence and severity. Elevated TSP\u20104 levels, particularly in early\u2010onset and severe cases, underscore its pathophysiological role and potential utility for clinical diagnosis and risk stratification in affected pregnancies.<\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/ijgo.70456","type":"journal-article","created":{"date-parts":[[2025,8,12]],"date-time":"2025-08-12T10:04:13Z","timestamp":1754993053000},"page":"345-352","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Diagnostic and prognostic role of thrombospondin\u20104 levels in pre\u2010eclampsia: Association with onset type, severity, and perinatal outcome"],"prefix":"10.1002","volume":"171","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8192-8841","authenticated-orcid":false,"given":"Ruken","family":"Dayanan","sequence":"first","affiliation":[{"name":"Department of Perinatology Ankara Etlik City Hospital Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9983-2306","authenticated-orcid":false,"given":"Dilara Duygulu","family":"Bulan","sequence":"additional","affiliation":[{"name":"Department of Perinatology Ankara Etlik City Hospital Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3182-4312","authenticated-orcid":false,"given":"Kadriye Yakut","family":"Yucel","sequence":"additional","affiliation":[{"name":"Department of Perinatology Ankara Etlik City Hospital Ankara 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