{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T08:13:47Z","timestamp":1771316027802,"version":"3.50.1"},"reference-count":16,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,8,21]],"date-time":"2025-08-21T00:00:00Z","timestamp":1755734400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,8,21]],"date-time":"2025-08-21T00:00:00Z","timestamp":1755734400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Gynecology &amp; Obste"],"published-print":{"date-parts":[[2026,1]]},"abstract":"Abstract<\/jats:title>\n \n Objective<\/jats:title>\n This study evaluates the diagnostic utility of serum calponin\u20102 (CNN\u20102) levels in the differential diagnosis and risk stratification of pregnancy of unknown location (PUL).<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n This prospective longitudinal study included 116 patients diagnosed with PUL between September 2022 and September 2023 at a tertiary hospital. Patients were classified according to final diagnosis into ectopic pregnancy (\n n<\/jats:italic>\n \u2009=\u200926), failed PUL (\n n<\/jats:italic>\n \u2009=\u200936), and intrauterine pregnancy (\n n<\/jats:italic>\n \u2009=\u200954) groups and risk stratified into high\u2010risk and low\u2010risk categories using the M6 model. Serum CNN\u20102 levels were measured at admission. The diagnostic performance of CNN\u20102 was assessed using receiver operating characteristic curve analysis.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Calponin\u20102 levels were significantly higher in ectopic pregnancy cases compared to failed PUL and intrauterine pregnancies (\n P<\/jats:italic>\n \u2009=\u20090.019 and\n P<\/jats:italic>\n \u2009<\u20090.001, respectively) and higher in failed PUL compared to intrauterine pregnancies (\n P<\/jats:italic>\n \u2009<\u20090.001). No difference was observed between viable and non\u2010viable intrauterine pregnancies (\n P<\/jats:italic>\n \u2009=\u20090.187). CNN\u20102 distinguished high\u2010risk from low\u2010risk PUL with 88.5% sensitivity and 78.9% specificity at a cut\u2010off of 0.17\u2009ng\/mL (AUC\u2009=\u20090.893,\n P<\/jats:italic>\n \u2009<\u20090.001). A CNN\u20102 level of \u22640.15\u2009ng\/mL identified intrauterine pregnancies with 90.7% sensitivity and 79% specificity (AUC\u2009=\u20090.904,\n P<\/jats:italic>\n \u2009<\u20090.001).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n Serum CNN\u20102 is a promising biomarker for early risk stratification and differential diagnosis in PUL. Its measurement might aid in timely identification of ectopic pregnancies and reduce reliance on serial \u03b2\u2010hCG testing. Further multicenter studies are needed to validate its clinical applicability.<\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/ijgo.70477","type":"journal-article","created":{"date-parts":[[2025,8,21]],"date-time":"2025-08-21T07:30:09Z","timestamp":1755761409000},"page":"406-411","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Evaluation of serum calponin\u20102 in the differential diagnosis of pregnancy of unknown location: A prospective analysis"],"prefix":"10.1002","volume":"172","author":[{"given":"Muhammed Ahsen","family":"Ogrenci","sequence":"first","affiliation":[{"name":"Pamukova State Hospital Sakarya Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gulten","family":"Ozgen","sequence":"additional","affiliation":[{"name":"Health Sciences University, Bursa Yuksek Ihtisas Educational and Research Hospital Bursa Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2902-9670","authenticated-orcid":false,"given":"Nergis Kender","family":"Erturk","sequence":"additional","affiliation":[{"name":"Health Sciences University, Bursa Yuksek Ihtisas Educational and Research Hospital Bursa Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Burcu","family":"Dincgez","sequence":"additional","affiliation":[{"name":"Health Sciences University, Bursa Yuksek Ihtisas Educational and Research Hospital Bursa Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,8,21]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.4015"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jogc.2021.01.002"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.semperi.2018.12.006"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.jbchem.a021428"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13277-014-2419-6"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.17701"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fob.2014.06.003"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.113.21.3725"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00233.2002"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M506991200"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2021.05.101"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.15864"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2010.09.006"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmt047"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2012.11.019"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/des440"}],"container-title":["International Journal of Gynecology & Obstetrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijgo.70477","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ijgo.70477","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijgo.70477","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T07:39:32Z","timestamp":1771313972000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1002\/ijgo.70477"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,21]]},"references-count":16,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1002\/ijgo.70477"],"URL":"https:\/\/doi.org\/10.1002\/ijgo.70477","archive":["Portico"],"relation":{},"ISSN":["0020-7292","1879-3479"],"issn-type":[{"value":"0020-7292","type":"print"},{"value":"1879-3479","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,21]]},"assertion":[{"value":"2025-06-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-08-10","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-08-21","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}